Evaluation of preferred binding regions on ubiquitin and IgG1 FC for interacting with multimodal cation exchange resins using DEPC labeling/mass spectrometry
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DOI: 10.1002/bit.28361
Abstract: There is significant interest in identifying the preferred binding domains of biological products to various chromatographic materials. In this work, we develop a biophysical technique that uses diethyl pyrocarbonate (DEPC) based covalent labeling in concert… read more here.
Keywords: cation exchange; binding regions; preferred binding; depc labeling ... See more keywords