DEPDC1B Promotes Melanoma Angiogenesis and Metastasis through Sequestration of Ubiquitin Ligase CDC16 to Stabilize Secreted SCUBE3
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202105226
Abstract: The ability of melanoma to acquire metastasis through the induction of angiogenesis is one of the major causes of skin cancer death. Here, it is found that high transcript levels of DEP domain containing 1B… read more here.
Keywords: metastasis; ubiquitin ligase; depdc1b; scube3 ... See more keywords
DEPDC1B knockdown inhibits the development of malignant melanoma through suppressing cell proliferation and inducing cell apoptosis.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2019.03.021
Abstract: Malignant melanoma (MM) remains the leading cause of skin cancer related death, which has very poor prognosis because of locoregional recurrence and distant metastasis. DEPDC1B (DEP domain-containing protein 1B), has been proved to be associated… read more here.
Keywords: apoptosis; cell proliferation; depdc1b knockdown; depdc1b ... See more keywords
DEPDC1B promotes colorectal cancer via facilitating cell proliferation and migration while inhibiting apoptosis
Sign Up to like & getrecommendations! Published in 2022 at "Cell Cycle"
DOI: 10.1080/15384101.2022.2110439
Abstract: ABSTRACT Colorectal cancer (CRC) is a common malignant tumor with strong invasiveness. Given the reported involvement of DEP domain-containing protein 1B (DEPDC1B) in the progression of some cancers, its role in CRC was explored in… read more here.
Keywords: cell; proliferation migration; apoptosis; depdc1b ... See more keywords
Aberrantly high DEPDC1B expression leads to poor prognosis in patients with lower-grade gliomas.
Sign Up to like & getrecommendations! Published in 2022 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202211_30130
Abstract: OBJECTIVE DEPDC1B, which encodes DEP domain-containing protein 1B, exerts pathogenic effects in diverse cancers, but no such effect has been reported in the case of lower-grade glioma (LGG). Therefore, we sought to investigate the relationship… read more here.
Keywords: prognosis; depdc1b; lgg; expression ... See more keywords
Identification and Validation of DEPDC1B as an Independent Early Diagnostic and Prognostic Biomarker in Liver Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2021.681809
Abstract: Liver hepatocellular carcinoma (LIHC) is one of the most lethal tumors worldwide, and while its detailed mechanism of occurrence remains unclear, an early diagnosis of LIHC could significantly improve the 5-years survival of LIHC patients.… read more here.
Keywords: hepatocellular carcinoma; depdc1b; expression; lihc patients ... See more keywords
Role of DEP domain-containing protein 1B (DEPDC1B) in epithelial ovarian cancer
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cancer"
DOI: 10.7150/jca.78423
Abstract: Aberrant expression of DEPDC1B (DEP domain-containing protein 1B) has been shown to be associated with various types of malignant tumors. However, little is known about the role of DEPDC1B in epithelial ovarian cancer (EOC). The… read more here.
Keywords: role; depdc1b; ovarian cancer; expression ... See more keywords