Chronic mTORC1 inhibition rescues behavioral and biochemical deficits resulting from neuronal Depdc5 loss in mice.
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DOI: 10.1093/hmg/ddz123
Abstract: DEPDC5 is now recognized as one of the genes most often implicated in familial/inherited focal epilepsy and brain malformations. Individuals with pathogenic variants in DEPDC5 are at risk for epilepsy, associated neuropsychiatric comorbidities, and Sudden… read more here.
Keywords: epilepsy; mice; depdc5cc mice; depdc5 loss ... See more keywords