Primary effusion lymphoma enhancer connectome links super-enhancers to dependency factors
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-20136-w
Abstract: Primary effusion lymphoma (PEL) has a very poor prognosis. To evaluate the contributions of enhancers/promoters interactions to PEL cell growth and survival, here we produce H3K27ac HiChIP datasets in PEL cells. This allows us to… read more here.
Keywords: enhancer connectome; dependency factors; connectome links; primary effusion ... See more keywords
Penalizing variances for higher dependency on factors
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DOI: 10.1080/14697688.2016.1220677
Abstract: Constructing equity portfolios to control for stock market volatility and unforeseen portfolio losses is critical for meeting investment objectives. Mean–variance analysis (Markowitz 1952, 1959) wa... read more here.
Keywords: penalizing variances; variances higher; dependency factors; finance ... See more keywords
A Virus-Packageable CRISPR System Identifies Host Dependency Factors Co-Opted by Multiple HIV-1 Strains
Sign Up to like & getrecommendations! Published in 2023 at "mBio"
DOI: 10.1128/mbio.00009-23
Abstract: With a small genome of ~9.2 kb that encodes 14 major proteins, HIV must hijack host cellular machinery to successfully establish infection. These host proteins necessary for HIV replication are called “dependency factors.” Whole-genome, and then… read more here.
Keywords: hiv strains; hiv; dependency factors; host ... See more keywords
The later stages of viral infection: An undiscovered country of host dependency factors
Sign Up to like & getrecommendations! Published in 2020 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1008777
Abstract: With their limited size and coding capacity, all viruses must exploit their host cells for the machinery and raw material they require for replication. At the same time, infected cells deploy an armada of antiviral… read more here.
Keywords: dependency factors; infection; later stages; host ... See more keywords
Elucidating the Host Interactome of EV-A71 2C Reveals Viral Dependency Factors
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2019.00636
Abstract: Viral protein 2C plays a critical role in EV-A71 replication. The discovery of 2C binding proteins will likely provide potential targets to treat EV-A71 infection. Here, we provide a global proteomic analysis of the human… read more here.
Keywords: interactome a71; dependency factors; host; exportin2 arfgap1 ... See more keywords