Force-Dependent Recruitment from the Myosin Off State Contributes to Length-Dependent Activation.
Sign Up to like & getrecommendations! Published in 2018 at "Biophysical journal"
DOI: 10.1016/j.bpj.2018.07.006
Abstract: Cardiac muscle develops more force when it is activated at longer lengths. The concentration of Ca2+ required to develop half-maximal force also decreases. These effects are known as length-dependent activation and are thought to play… read more here.
Keywords: state; myosin; length dependent; force ... See more keywords
Redox Dependent Activation of NF-kB Signaling in Cancer via Superoxide-Induced Phosphorylation of IKK
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.10.161
Abstract: Evidence over the years has highlighted the importance of intracellular redox status in determining cell fate. To date, our work has shown that a pro-oxidant intracellular milieu, particularly a mild increase in superoxide (O2•‒) promotes… read more here.
Keywords: superoxide; activation; cancer; redox dependent ... See more keywords
Adenosine-Dependent Activation Mechanism of Prodrugs Targeting an Aminoacyl-tRNA Synthetase
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c04808
Abstract: Prodrugs have little or no pharmacological activity and are converted to active drugs in the body by enzymes, metabolic reactions, or through human-controlled actions. However, prodrugs promoting their chemical bioconversion without any of these processes… read more here.
Keywords: trna synthetase; adenosine dependent; activation mechanism; dependent activation ... See more keywords
AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-14812-0
Abstract: The AMP-activated protein kinase (AMPK) is a master sensor of the cellular energy status that is crucial for the adaptive response to limited energy availability. AMPK is implicated in the regulation of many cellular processes,… read more here.
Keywords: cyclin; ampk dependent; dependent activation; cyclin cdk16 ... See more keywords
ULK3-dependent activation of GLI1 promotes DNMT3A expression upon autophagy induction
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2039993
Abstract: ABSTRACT Macroautophagy/autophagy is a tightly regulated catabolic process, which contributes at baseline level to cellular homeostasis, and upon its stimulation to the adaptive cellular response to intra- and extracellular stress stimuli. Decrease of autophagy activity… read more here.
Keywords: upon autophagy; gli1; expression; dependent activation ... See more keywords
RpoN/Sfa2-dependent activation of the Pseudomonas aeruginosa H2-T6SS and its cognate arsenal of antibacterial toxins
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab1254
Abstract: Abstract Pseudomonas aeruginosa uses three type six secretion systems (H1-, H2- and H3-T6SS) to manipulate its environment, subvert host cells and for microbial competition. These T6SS machines are loaded with a variety of effectors/toxins, many… read more here.
Keywords: dependent activation; t6ss; pseudomonas aeruginosa; rpon sfa2 ... See more keywords
Length-Dependent Activation of Contractility and Ca-Transient Kinetics in Auxotonically Contracting Isolated Rat Ventricular Cardiomyocytes
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2019.01473
Abstract: Length-dependent activation (LDA) of contraction is an important mechanism of proper myocardial function that is often blunted in diseases accompanied by deficient contractility and impaired calcium homeostasis. We evaluated how the extent of LDA is… read more here.
Keywords: rat ventricular; length dependent; calcium; transient ... See more keywords