Articles with "dependent adenovirus" as a keyword



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Ultralow-dose binary oncolytic/helper-dependent adenovirus promotes antitumor activity in preclinical and clinical studies

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Published in 2023 at "Science Advances"

DOI: 10.1126/sciadv.ade6790

Abstract: We show that a binary oncolytic/helper-dependent adenovirus (CAdVEC) that both lyses tumor cells and locally expresses the proinflammatory cytokine IL-12 and PD-L1 blocking antibody has potent antitumor activity in humanized mouse models. On the basis… read more here.

Keywords: helper dependent; oncolytic helper; antitumor activity; binary oncolytic ... See more keywords