Ph-Induced Oligomerization of the Voltage Dependent Anion Channel
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.1018
Abstract: The Voltage-Dependent Anion Channel (VDAC) is the most abundant protein in the outer mitochondrial membrane facilitating the passage of ions and metabolites between the cytoplasm and the intermembrane space. In addition to its critical role… read more here.
Keywords: dependent anion; anion channel; microscopy; induced oligomerization ... See more keywords
The N-Terminal Segment of the Voltage-Dependent Anion Channel: A Possible Membrane-Bound Intermediate in Pore Unbinding.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2018.09.015
Abstract: The voltage-dependent anion channel (VDAC) resides in the outer mitochondrial membrane and can adopt a closed or open configuration, most likely depending on whether the N-terminal segment (NTS) occupies the pore or protrudes into the… read more here.
Keywords: dependent anion; membrane bound; anion channel; voltage dependent ... See more keywords
Mapping the N-Terminal Hexokinase-I Binding Site onto Voltage-Dependent Anion Channel-1 To Block Peripheral Nerve Demyelination.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00411
Abstract: The voltage-dependent anion channel (VDAC), the most abundant protein on the outer mitochondrial membrane, is implicated in ATP, ion and metabolite exchange with cell compartments. In particular, the VDAC participates in cytoplasmic and mitochondrial Ca2+… read more here.
Keywords: dependent anion; peripheral nerve; voltage dependent; nerve demyelination ... See more keywords
The Single Residue K12 Governs the Exceptional Voltage Sensitivity of Mitochondrial Voltage-Dependent Anion Channel Gating.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c03316
Abstract: The voltage-dependent anion channel (VDAC) is a β-barrel channel of the mitochondrial outer membrane (MOM) that passively transports ions, metabolites, polypeptides, and single-stranded DNA. VDAC responds to a transmembrane potential by "gating," i.e. transitioning to… read more here.
Keywords: dependent anion; residue k12; voltage; voltage dependent ... See more keywords
MicroED structure of lipid-embedded mammalian mitochondrial voltage-dependent anion channel.
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2020010117
Abstract: A structure of the murine voltage-dependent anion channel (VDAC) was determined by microcrystal electron diffraction (MicroED). Microcrystals of an essential mutant of VDAC grew in a viscous bicelle suspension, making it unsuitable for conventional X-ray… read more here.
Keywords: dependent anion; voltage dependent; anion channel; structure ... See more keywords
Voltage-dependent anion channel proteins associate with dynamic Bamboo mosaic virus-induced complexes.
Sign Up to like & getrecommendations! Published in 2021 at "Plant physiology"
DOI: 10.1093/plphys/kiab519
Abstract: Infection cycles of viruses are highly dependent on membrane-associated host factors. To uncover the infection cycle of Bamboo mosaic virus (BaMV) in detail, we purified the membrane-associated viral complexes from infected Nicotiana benthamiana plants and… read more here.
Keywords: dependent anion; mosaic virus; voltage dependent; bamv ... See more keywords
Voltage-Dependent Anion Channel 1 As an Emerging Drug Target for Novel Anti-Cancer Therapeutics
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2017.00154
Abstract: Cancer cells share several properties, high proliferation potential, reprogramed metabolism, and resistance to apoptotic cues. Acquiring these hallmarks involves changes in key oncogenes and non-oncogenes essential for cancer cell survival and prosperity, and is accompanied… read more here.
Keywords: dependent anion; vdac1; voltage dependent; cancer cell ... See more keywords
Protective Effect of Treated Olive Mill Wastewater on Target Bacteria and Mitochondrial Voltage-Dependent Anion-Selective Channel 1
Sign Up to like & getrecommendations! Published in 2023 at "Antioxidants"
DOI: 10.3390/antiox12020322
Abstract: Olive mill wastewater, a by-product of the olive oil industry, represents an important resource, rich in bioactive compounds with antioxidant activity. In this study, two strategies to concentrate the bioactive components were used: the tangential… read more here.
Keywords: mill wastewater; olive mill; dependent anion; voltage dependent ... See more keywords
The Molecular Mechanism of Human Voltage-Dependent Anion Channel 1 Blockade by the Metallofullerenol Gd@C82(OH)22: An In Silico Study
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12010123
Abstract: The endohedral metallofullerenol Gd@C82(OH)22 has been identified as a possible antineoplastic agent that can inhibit both the growth and metastasis of cancer cells. Despite these potentially important effects, our understanding of the interactions between Gd@C82(OH)22… read more here.
Keywords: human voltage; anion channel; c82; dependent anion ... See more keywords