Characterization of a humanized PD-L1 blocking antibody with pH-dependent antigen binding in a humanized syngenic tumor model.
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DOI: 10.1200/jco.2017.35.7_suppl.81
Abstract: 81Background: Checkpoint inhibition is a promising approach for cancer treatment with durable responses and survival benefits. Currently, immune-checkpoint inhibitors are delivered at maximally tolerated doses, resulting in significant toxicities and cost burden. There is significant… read more here.
Keywords: tumor model; antigen binding; dependent antigen; antibody dependent ... See more keywords