pH-Dependent Conformational Switching of Amide Bonds─from Full trans to Full cis and Vice Versa.
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DOI: 10.1021/acs.orglett.2c00938
Abstract: Strategies enabling the pH-dependent conformational switching of amide bonds from trans to cis, and vice versa, are yet limited in the sense that, in a suitable pH range, one rotamer may be stabilized to a… read more here.
Keywords: switching amide; cis vice; amide bonds; dependent conformational ... See more keywords
Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor
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DOI: 10.1038/cr.2017.42
Abstract: T-cell receptor-CD3 complex (TCR) is a versatile signaling machine that can initiate antigen-specific immune responses based on various biochemical changes of CD3 cytoplasmic domains, but the underlying structural basis remains elusive. Here we developed biophysical… read more here.
Keywords: dependent conformational; conformational dynamics; cell receptor; lipid dependent ... See more keywords
Inducing a pH-dependent conformational response by competitive binding to Zn2+ of a series of chiral ligands of disparate basicity
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DOI: 10.1039/d1sc06812a
Abstract: Molecules that change shape in response to environmental conditions are central to biological molecular communication devices and their synthetic chemical analogues. Here we report a molecular system in which a series of chiral anionic ligands… read more here.
Keywords: response; dependent conformational; series chiral; conformational response ... See more keywords
The temperature-dependent conformational ensemble of SARS-CoV-2 main protease (Mpro)
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DOI: 10.1107/s2052252522007497
Abstract: X-ray crystallography at variable temperature for SARS-CoV-2 Mpro reveals a complex conformational landscape, including a mobile metal at the catalytic dyad, mercurial conformational heterogeneity at various sites, and an intramolecular network bridging the active site… read more here.
Keywords: temperature dependent; ensemble sars; temperature; dependent conformational ... See more keywords