Cell origin–dependent cooperativity of mutant Dnmt3a and Npm1 in clonal hematopoiesis and myeloid malignancy
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DOI: 10.1182/bloodadvances.2022006968
Abstract: Key Points Selective advantage induced by clonal hematopoiesis-associated mutation in Dnmt3a is specific to the HSC compartment. Npm1 mutation alters chromatin accessibility in a cell-context and Dnmt3a mutation-dependent manner. read more here.
Keywords: dependent cooperativity; origin dependent; dnmt3a; cell origin ... See more keywords