Cholesterol‐dependent cytolysins: The outstanding questions
Sign Up to like & getrecommendations! Published in 2022 at "IUBMB Life"
DOI: 10.1002/iub.2661
Abstract: The cholesterol‐dependent cytolysins (CDCs) are a major family of bacterial pore‐forming proteins secreted as virulence factors by Gram‐positive bacterial species. CDCs are produced as soluble, monomeric proteins that bind specifically to cholesterol‐rich membranes, where they… read more here.
Keywords: dependent cytolysins; outstanding questions; cytolysins outstanding; cholesterol dependent ... See more keywords
Reprogramming cholesterol metabolism in macrophages and its role in host defense against cholesterol-dependent cytolysins
Sign Up to like & getrecommendations! Published in 2022 at "Cellular and Molecular Immunology"
DOI: 10.1038/s41423-021-00827-0
Abstract: Cholesterol is a critical lipid for all mammalian cells, ensuring proper membrane integrity, fluidity, and biochemical function. Accumulating evidence indicates that macrophages rapidly and profoundly reprogram their cholesterol metabolism in response to activation signals to… read more here.
Keywords: dependent cytolysins; cholesterol; cholesterol dependent; host defense ... See more keywords
Cells Responding to Closely Related Cholesterol-Dependent Cytolysins Release Extracellular Vesicles with a Common Proteomic Content Including Membrane Repair Proteins
Sign Up to like & getrecommendations! Published in 2022 at "Toxins"
DOI: 10.3390/toxins15010004
Abstract: The plasma membrane (PM) protects cells from extracellular threats and supports cellular homeostasis. Some pathogens produce pore-forming toxins (PFTs) that disrupt PM integrity by forming transmembrane pores. High PFT concentrations cause massive damage leading to… read more here.
Keywords: extracellular vesicles; repair proteins; dependent cytolysins; cholesterol dependent ... See more keywords