Hexamerization-enhanced CD20 antibody mediates complement-dependent cytotoxicity in serum genetically deficient in C9.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical immunology"
DOI: 10.1016/j.clim.2017.05.016
Abstract: We examined complement-dependent cytotoxicity (CDC) by hexamer formation-enhanced CD20 mAb Hx-7D8 of patient-derived chronic lymphocytic leukemia (CLL) cells that are relatively resistant to CDC. CDC was analyzed in normal human serum (NHS) and serum from… read more here.
Keywords: complement dependent; dependent cytotoxicity; enhanced cd20; cdc ... See more keywords
Synthesis of crystalline zinc hydroxystannate and its thermally driven amorphization and recrystallization into zinc orthostannate and their phase-dependent cytotoxicity evaluation
Sign Up to like & getrecommendations! Published in 2020 at "Materials Chemistry and Physics"
DOI: 10.1016/j.matchemphys.2020.122946
Abstract: Abstract Engineered metal-oxide nanoparticles have greatly been used in various bio-applications, but their physicochemical properties change dramatically within a bio-system. Therefore, the development of new metal-oxide nanoparticles and proper understanding of their toxicity profile in… read more here.
Keywords: zinc orthostannate; zinc; crystalline zinc; dependent cytotoxicity ... See more keywords
CDC (compliment dependent cytotoxicity testing) and Donor Specific Antibody (DSA) Detection by Single Antigen Beads (SAB) Assay for Acute Antibody Mediated Rejection (ABMR) Risk Assessment
Sign Up to like & getrecommendations! Published in 2017 at "Transplantation"
DOI: 10.1097/01.tp.0000520368.38205.54
Abstract: Forty-two patients were evaluated for donor specific anti HLA sensi tion before they recivied ABO incompatible kidney transplantation. E recipient was evaluated by complement dependent cytotoxicity (C crossmatch, flow crossmatch, single antigen bead assay (SAB)… read more here.
Keywords: antibody; dependent cytotoxicity; abmr; antibody mediated ... See more keywords
Successful kidney transplantation across a positive complement-dependent cytotoxicity crossmatch by using C1q assay-directed, bortezomib-assisted desensitization
Sign Up to like & getrecommendations! Published in 2017 at "Medicine"
DOI: 10.1097/md.0000000000008145
Abstract: Rationale: Human leukocyte antigen (HLA) is the major immunologic barrier in kidney transplantation (KT). Various desensitization protocols to overcome the HLA barrier have increased the opportunity for transplantation in sensitized patients. In addition, technological advances… read more here.
Keywords: complement dependent; kidney transplantation; dependent cytotoxicity; transplantation ... See more keywords
Trastuzumab/pertuzumab combination therapy stimulates antitumor responses through complement-dependent cytotoxicity and phagocytosis
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.155636
Abstract: Two HER2-specific mAbs, trastuzumab and pertuzumab (T+P), combined with chemotherapy comprise standard-of-care treatment for advanced HER2+ breast cancers (BC). While this antibody combination is highly effective, its synergistic mechanism-of-action (MOA) remains incompletely understood. Past studies… read more here.
Keywords: complement dependent; her2; combination; therapy ... See more keywords
Bispecific mAb2 Antibodies Targeting CD59 Enhance the Complement-Dependent Cytotoxicity Mediated by Rituximab
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23095208
Abstract: Inhibition of complement activation via the overexpression of complement-regulatory proteins (CRPs), most notably CD46, CD55 and CD59, is an efficient mechanism of disguise of cancer cells from a host immune system. This phenomenon extends to… read more here.
Keywords: cd20; complement dependent; complement; dependent cytotoxicity ... See more keywords
Dose-Dependent Cytotoxicity of Polypropylene Microplastics (PP-MPs) in Two Freshwater Fishes
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232213878
Abstract: The massive accumulation of plastics over the decades in the aquatic environment has led to the dispersion of plastic components in aquatic ecosystems, invading the food webs. Plastics fragmented into microplastics can be bioaccumulated by… read more here.
Keywords: microplastics mps; dose dependent; dependent cytotoxicity; cytotoxicity polypropylene ... See more keywords