Novel Oxygen-Dependent Degradable Immunotoxin Regulated by the Ubiquitin-Proteasome System Reduces Nonspecific Cytotoxicity.
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DOI: 10.1021/acs.molpharmaceut.2c00503
Abstract: The use of bacterial toxins as antitumor agents has received considerable attention. Immunotoxins based on antigen recognition of single-chain antibodies have been widely explored for cancer therapy. Despite their impressive killing effect on tumor cells,… read more here.
Keywords: oxygen dependent; ubiquitin proteasome; degradable immunotoxin; oxygen ... See more keywords