Frequency-dependent drug screening using optogenetic stimulation of human iPSC-derived cardiomyocytes
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DOI: 10.1038/s41598-017-09760-7
Abstract: Side effects on cardiac ion channels are one major reason for new drugs to fail during preclinical evaluation. Herein we propose a simple optogenetic screening tool measuring extracellular field potentials (FP) from paced cardiomyocytes to… read more here.
Keywords: dependent drug; drug; drug screening; derived cardiomyocytes ... See more keywords
Crosslinking-Dependent Drug Kinetics in Hydrogels for Ophthalmic Delivery
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DOI: 10.3390/polym14020248
Abstract: Drug-diffusion kinetics in 2-hydroxyethyl methacrylate hydrogels were studied as a function of the crosslinking density and porosity. By varying the concentration of the crosslinker, tetraethylene glycol dimethacrylate, we demonstrated how the release of Timolol maleate… read more here.
Keywords: crosslinking dependent; drug kinetics; drug; delivery ... See more keywords