Cholesterol-dependent endocytosis of GPCRs: implications in pathophysiology and therapeutics.
Sign Up to like & getrecommendations! Published in 2021 at "Biophysical reviews"
DOI: 10.1007/s12551-021-00878-7
Abstract: G protein-coupled receptors (GPCRs) are the largest family of transmembrane proteins that relay extracellular signals across the plasma membrane and elicit an intricate cascade of cellular signaling events. A significantly large fraction of available drugs… read more here.
Keywords: dependent endocytosis; endocytosis gpcrs; membrane; gpcrs ... See more keywords
Porcine sapelovirus enters PK-15 cells via caveolae-dependent endocytosis and requires Rab7 and Rab11
Sign Up to like & getrecommendations! Published in 2019 at "Virology"
DOI: 10.1016/j.virol.2019.01.009
Abstract: Abstract To comprehensively understand the endocytosis of Sapelovirus A (PSV) entry into PK-15 cells, we studied PSV infection in the context of cell perturbations through drug inhibition, siRNA silencing and overexpression of dominant negative (DN)… read more here.
Keywords: sapelovirus; endocytosis; caveolae dependent; rab7 rab11 ... See more keywords
Size-dependent endocytosis and a dynamic-release model of nanoparticles.
Sign Up to like & getrecommendations! Published in 2018 at "Nanoscale"
DOI: 10.1039/c8nr00830b
Abstract: Polymeric nanoparticles for drug delivery are attracting broad interest along with the rapid development of biomedical and healthcare research. Here, we prepared a series of nanocapsules via electrostatic precipitation of chitosan and lecithin micelles. These… read more here.
Keywords: endocytosis dynamic; size dependent; model; dynamic release ... See more keywords
pH-dependent endocytosis mechanisms for influenza A and SARS-coronavirus
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2023.1190463
Abstract: The ongoing SARS-CoV-2 pandemic and the influenza epidemics have revived the interest in understanding how these highly contagious enveloped viruses respond to alterations in the physicochemical properties of their microenvironment. By understanding the mechanisms and… read more here.
Keywords: dependent endocytosis; endocytosis mechanisms; influenza sars; sars coronavirus ... See more keywords
Receptor-Dependent Endocytosis Mediates α-Synuclein Oligomer Transport Into Red Blood Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.899892
Abstract: Detection of oligomeric α-synuclein (o-α-Syn) in red blood cells (RBCs) has been shown to be promising in diagnosing Parkinson’s disease and other synucleinopathies. However, if RBC o-α-Syn derive from plasma and can reflect changes of… read more here.
Keywords: dependent endocytosis; red blood; receptor dependent; blood cells ... See more keywords
Energy-Dependent Endocytosis Is Involved in the Absorption of Indomethacin Nanoparticles in the Small Intestine
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20030476
Abstract: We previously reported that oral formulations containing indomethacin nanoparticles (IND-NPs) showed high bioavailability, and, consequently, improved therapeutic effects and reduced injury to the small intestine. However, the pathway for the transintestinal penetration of nanoparticles remained… read more here.
Keywords: penetration; endocytosis; indomethacin nanoparticles; small intestine ... See more keywords
Ubiquitin C-terminal Hydrolase L1 Regulates Lipid Raft-dependent Endocytosis
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Neurobiology"
DOI: 10.5607/en.2018.27.5.377
Abstract: Ubiquitin C-terminal hydrolase L1 (UCH-L1) is a deubiquitinating enzyme that is highly expressed in neurons, and gathering evidence indicates that UCH-L1 may play pathogenic roles in many neurodegenerative disorders such as Alzheimer's disease and Parkinson's… read more here.
Keywords: ubiquitin terminal; regulates lipid; raft dependent; dependent endocytosis ... See more keywords