Molecular Dynamics Simulation reveals the mechanism by which the Influenza Cap-dependent Endonuclease acquires resistance against Baloxavir marboxil
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DOI: 10.1038/s41598-019-53945-1
Abstract: Baloxavir marboxil (BXM), an antiviral drug for influenza virus, inhibits RNA replication by binding to RNA replication cap-dependent endonuclease (CEN) of influenza A and B viruses. Although this drug was only approved by the FDA… read more here.
Keywords: molecular dynamics; dependent endonuclease; simulation; baloxavir marboxil ... See more keywords
Identification of cap-dependent endonuclease inhibitors with broad-spectrum activity against bunyaviruses
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2206104119
Abstract: Significance Bunyaviruses, like influenza viruses, possess a cap-dependent endonuclease (CEN) that mediates the critical cap-snatching step of viral RNA transcription. We identified the antibunyavirus compounds among influenza CEN inhibitors and identified specific structures involved in… read more here.
Keywords: identification cap; cap dependent; cap; dependent endonuclease ... See more keywords
Baloxavir Marboxil: The First Cap-Dependent Endonuclease Inhibitor for the Treatment of Influenza
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DOI: 10.1177/1060028019826565
Abstract: Objective: To review the pharmacology, pharmacokinetics, clinical trials, and clinical implications of baloxavir marboxil. Data Sources: A MEDLINE search was conducted using the terms baloxavir, baloxavir marboxil, cap-dependent endonuclease inhibitor, and polymerase acidic endonuclease inhibitor.… read more here.
Keywords: baloxavir; dependent endonuclease; baloxavir marboxil; endonuclease inhibitor ... See more keywords