Model for surface-dependent factor XII activation: the roles of factor XII heavy chain domains
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DOI: 10.1182/bloodadvances.2021005976
Abstract: Key Points The FXII EGF1 domain promotes surface binding, FXII activation on surfaces, and FXIIa activation of prekallikrein on surfaces. The FXII FN2 and KNG domains are part of a mechanism that restricts FXII activation… read more here.
Keywords: surface dependent; dependent factor; xii activation; model surface ... See more keywords
INR and vitamin K–dependent factor levels after vitamin K antagonist reversal with 4F-PCC or plasma
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DOI: 10.1182/bloodadvances.2022009015
Abstract: Key Points • 4F-PCC rapidly restores vitamin K–dependent factors to hemostatic levels in patients treated with VKA immediately after infusion.• Postreversal INR may not accurately reflect vitamin K–dependent factor restoration after a 4F–PCC infusion. read more here.
Keywords: dependent factor; vitamin dependent; inr vitamin; factor levels ... See more keywords