Toxicity‐dependent feasibility bounds for the escalation with overdose control approach in phase I cancer trials
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DOI: 10.1002/sim.7280
Abstract: Phase I trials of anti‐cancer therapies aim to identify a maximum tolerated dose (MTD), defined as the dose that causes unacceptable toxicity in a target proportion of patients. Both rule‐based and model‐based methods have been… read more here.
Keywords: dependent feasibility; feasibility; approach; escalation ... See more keywords