SIRT3 inhibits gallbladder cancer by induction of AKT-dependent ferroptosis and blockade of epithelial-mesenchymal transition.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer letters"
DOI: 10.1016/j.canlet.2021.04.007
Abstract: Dysfunction of Sirtuin 3 (SIRT3), an NAD+-dependent histone deacetylase, impairs varied mitochondrial metabolic pathways in human cancer. Here, we explored suppressive activity of SIRT3 in the progression of gallbladder cancer (GBC). Expression levels of SIRT3… read more here.
Keywords: akt dependent; dependent ferroptosis; cancer; gallbladder cancer ... See more keywords
Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity.
Sign Up to like & getrecommendations! Published in 2020 at "JCI insight"
DOI: 10.1172/jci.insight.132747
Abstract: Doxorubicin (DOX), a chemotherapeutic agent, induces a cardiotoxicity referred to as doxorubicin-induced cardiomyopathy (DIC). This cardiotoxicity often limits chemotherapy for malignancies and is associated with poor prognosis. However, the molecular mechanism underlying this cardiotoxicity is… read more here.
Keywords: dependent ferroptosis; mitochondria dependent; ferroptosis; cardiotoxicity ... See more keywords
Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity
Sign Up to like & getrecommendations! Published in 2023 at "JCI Insight"
DOI: 10.1172/jci.insight.169756
Abstract: , leading to mitochondria-dependent ferroptosis; we also show that mitochondria-dependent ferroptosis is a major cause of DOX cardiotoxicity. In DIC mice, the left ventricular ejection fraction was significantly impaired, and fibrosis and TUNEL + cells… read more here.
Keywords: dox; mitochondria dependent; cardiotoxicity; dependent ferroptosis ... See more keywords
Autophagy-Dependent Ferroptosis-Related Signature is Closely Associated with the Prognosis and Tumor Immune Escape of Patients with Glioma
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DOI: 10.2147/ijgm.s343046
Abstract: Background Ferroptosis is an autophagy-dependent form of cell death, sometimes called “ferritinophagy”. Its related pathway has been proven to regulate the programmed death of glioma stem cells. Mining autophagy-dependent ferroptosis-related gene (AD-FRG) signature could facilitate… read more here.
Keywords: signature; ferroptosis; tumor; autophagy dependent ... See more keywords
Autophagy-dependent ferroptosis as a potential treatment for glioblastoma
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1091118
Abstract: Glioblastoma (GBM) is the most common malignant primary brain tumor with a poor 5-year survival rate. Autophagy is a conserved intracellular degradation system that plays a dual role in GBM pathogenesis and therapy. On one… read more here.
Keywords: autophagy dependent; glioblastoma; potential treatment; ferroptosis potential ... See more keywords