Roquin-dependent gene regulation in immune-mediated diseases and future therapies.
Sign Up to like & getrecommendations! Published in 2022 at "International immunology"
DOI: 10.1093/intimm/dxac059
Abstract: The RNA-binding proteins Roquin-1/2 and Regnase-1 exert essential regulation by controlling proinflammatory mRNA expression to prevent autoimmune disease. More recently, inhibition of this post-transcriptional gene regulatory program has been demonstrated to enable enhanced anti-tumor responses… read more here.
Keywords: gene regulation; regulation; gene; regulation immune ... See more keywords
Modeling confinement and reversibility of threshold-dependent gene drive systems in spatially-explicit Aedes aegypti populations
Sign Up to like & getrecommendations! Published in 2020 at "BMC Biology"
DOI: 10.1186/s12915-020-0759-9
Abstract: The discovery of CRISPR-based gene editing and its application to homing-based gene drive systems has been greeted with excitement, for its potential to control mosquito-borne diseases on a wide scale, and concern, for the invasiveness… read more here.
Keywords: gene drive; threshold dependent; drive systems; dependent gene ... See more keywords
Ligand dependent gene regulation by transient ERα clustered enhancers
Sign Up to like & getrecommendations! Published in 2020 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1008516
Abstract: Unliganded Estrogen receptor alpha (ERα) has been implicated in ligand-dependent gene regulation. Upon ligand exposure, ERα binds to several EREs relatively proximal to the pre-marked, unliganded ERα-bound sites and affects transient but robust gene expression.… read more here.
Keywords: gene regulation; clustered enhancers; dependent gene; gene ... See more keywords
Segment-Dependent Gene Expression Profiling of the Cartilaginous Fish Nephron Using Laser Microdissection for Functional Characterization of Nephron at Segment Levels
Sign Up to like & getrecommendations! Published in 2023 at "Zoological Science"
DOI: 10.2108/zs220092
Abstract: For adaptation to a high salinity marine environment, cartilaginous fishes have evolved a ureosmotic strategy. They have a highly elaborate “four-loop nephron” in the kidney, which is considered to be important for reabsorption of urea… read more here.
Keywords: nephron; segment dependent; loop; gene expression ... See more keywords