Asymmetric catalysis by flavin-dependent halogenases.
Sign Up to like & getrecommendations! Published in 2023 at "Chirality"
DOI: 10.1002/chir.23550
Abstract: In nature, flavin-dependent halogenases (FDHs) catalyze site-selective chlorination and bromination of aromatic natural products. This ability has led to extensive efforts to engineer FDHs for selective chlorination, bromination, and iodination of electron rich aromatic compounds.… read more here.
Keywords: flavin dependent; catalysis; asymmetric catalysis; dependent halogenases ... See more keywords
Engineering Fe(II)/α-Ketoglutarate-Dependent Halogenases and Desaturases.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00115
Abstract: Fe(II)/α-ketoglutarate-dependent dioxygenases (α-KGDs) are widespread enzymes in aerobic biology and serve a remarkable array of biological functions, including roles in collagen biosynthesis, plant and animal development, transcriptional regulation, nucleic acid modification, and secondary metabolite biosynthesis.… read more here.
Keywords: engineering ketoglutarate; ketoglutarate dependent; biology; engineering ... See more keywords
Flavin-dependent halogenases catalyze enantioselective olefin halocyclization
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-23503-3
Abstract: Halocyclization of alkenes is a powerful bond-forming tool in synthetic organic chemistry and a key step in natural product biosynthesis, but catalyzing halocyclization with high enantioselectivity remains a challenging task. Identifying suitable enzymes that catalyze… read more here.
Keywords: dependent halogenases; flavin dependent; enantioselective olefin; catalyze enantioselective ... See more keywords