Structure, mechanism, and inhibition of the zinc-dependent histone deacetylases.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in structural biology"
DOI: 10.1016/j.sbi.2019.01.004
Abstract: Zinc-dependent histone deacetylases (HDACs) regulate the biological function of histone and non-histone proteins through the hydrolysis of acetyllysine side chains to yield free lysine and acetate. Certain HDAC isozymes exhibit alternative catalytic activities, such as… read more here.
Keywords: zinc dependent; structure mechanism; dependent histone; histone deacetylases ... See more keywords
Human cytomegalovirus lytic infection inhibits replication-dependent histone synthesis and requires stem loop binding protein function
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2122174119
Abstract: Significance Until now, it was not known if, how, or why pathogenic human viruses might modulate the de novo production of the replication-dependent (RD) histone proteins that decorate their DNA genomes within infected cells. Our… read more here.
Keywords: histone; replication dependent; replication; dependent histone ... See more keywords