Ubiquitin-Dependent and -Independent Roles of E3 Ligase RIPLET in Innate Immunity
Sign Up to like & getrecommendations! Published in 2019 at "Cell"
DOI: 10.1016/j.cell.2019.03.017
Abstract: The conventional view posits that E3 ligases function primarily through conjugating ubiquitin (Ub) to their substrate molecules. We report here that RIPLET, an essential E3 ligase in antiviral immunity, promotes the antiviral signaling activity of… read more here.
Keywords: immunity; rig; dependent independent; ubiquitin dependent ... See more keywords
Small Molecule Inhibits Metal-Dependent and -Independent Multifaceted Toxicity of Alzheimer's Disease.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.9b00216
Abstract: Alzheimer's disease (AD) is one of the most devastating forms of dementia, without reliable treatments to cure, delay the onset, or prevent the disease progression. The proposed toxic mechanisms of AD include amyloidogenesis of amyloid… read more here.
Keywords: multifaceted toxicity; alzheimer disease; dependent independent; toxicity ... See more keywords
FDX1-dependent and independent mechanisms of elesclomol-mediated intracellular copper delivery
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2216722120
Abstract: Significance Genetic defects in copper transport to cuproenzymes result in infantile disorders for which no effective therapies are currently available. Recent studies have uncovered the therapeutic potential of elesclomol, a copper-transporting drug, in the treatment… read more here.
Keywords: dependent independent; copper; independent mechanisms; fdx1 dependent ... See more keywords
The pVHL neglected functions, a tale of hypoxia-dependent and -independent regulations in cancer
Sign Up to like & getrecommendations! Published in 2020 at "Open Biology"
DOI: 10.1098/rsob.200109
Abstract: The von Hippel–Lindau protein (pVHL) is a tumour suppressor mainly known for its role as master regulator of hypoxia-inducible factor (HIF) activity. Functional inactivation of pVHL is causative of the von Hippel–Lindau disease, an inherited… read more here.
Keywords: pvhl; dependent independent; neglected functions; pvhl neglected ... See more keywords
β-Amyloid–Dependent and –Independent Genetic Pathways Regulating CSF Tau Biomarkers in Alzheimer Disease
Sign Up to like & getrecommendations! Published in 2022 at "Neurology"
DOI: 10.1212/wnl.0000000000200605
Abstract: Background and Objectives Abnormal metabolism of β-amyloid (Aβ) and soluble phosphorylated tau (P-tau), as well as neurodegeneration, are key components of Alzheimer disease (AD), but it is unclear how these different processes are related to… read more here.
Keywords: dependent independent; genetic pathways; tau; csf ... See more keywords
The role of activation of two different sGC binding sites by NO‐dependent and NO‐independent mechanisms in the regulation of SACs in rat ventricular cardiomyocytes
Sign Up to like & getrecommendations! Published in 2022 at "Physiological Reports"
DOI: 10.14814/phy2.15246
Abstract: The mechanoelectrical feedback (MEF) mechanism in the heart that plays a significant role in the occurrence of arrhythmias, involves cation flux through cation nonselective stretch‐activated channels (SACs). It is well known that nitric oxide (NO)… read more here.
Keywords: ventricular cardiomyocytes; dependent independent; cell; regulation ... See more keywords
Androgen receptor-dependent and -independent mechanisms driving prostate cancer progression: Opportunities for therapeutic targeting from multiple angles
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.12554
Abstract: Despite aggressive treatment for localized cancer, prostate cancer (PC) remains a leading cause of cancer-related death for American men due to a subset of patients progressing to lethal and incurable metastatic castrate-resistant prostate cancer (CRPC).… read more here.
Keywords: dependent independent; prostate cancer; cancer; progression ... See more keywords
PI(4,5)P2-dependent and -independent roles of PI4P in the control of hormone secretion by pituitary cells
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2023.1118744
Abstract: Plasma membrane and organelle membranes are home to seven phosphoinositides, an important class of low-abundance anionic signaling lipids that contribute to cellular functions by recruiting cytoplasmic proteins or interacting with the cytoplasmic domains of membrane… read more here.
Keywords: dependent independent; pituitary cells; hormone; control ... See more keywords
Sirtuin 3 Dependent and Independent Effects of NAD+ to Suppress Vascular Inflammation and Improve Endothelial Function in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11040706
Abstract: Atherosclerosis is initiated by endothelial cell dysfunction and vascular inflammation under the condition of hyperlipidemia. Sirtuin 3 (SIRT3) is a nicotinamide adenine dinucleotide (NAD+)-dependent mitochondrial deacetylase, which plays a key role in maintaining normal mitochondrial… read more here.
Keywords: improve endothelial; dependent independent; vascular inflammation; inflammation ... See more keywords
The K+-Dependent and -Independent Pyruvate Kinases Acquire the Active Conformation by Different Mechanisms
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031347
Abstract: Eukarya pyruvate kinases possess glutamate at position 117 (numbering of rabbit muscle enzyme), whereas bacteria have either glutamate or lysine. Those with E117 are K+-dependent, whereas those with K117 are K+-independent. In a phylogenetic tree,… read more here.
Keywords: pyruvate kinases; dependent independent; independent pyruvate; active conformation ... See more keywords
Androgen Receptor Upregulates Mucosa-Associated Lymphoid Tissue 1 to Induce NF-κB Activity via Androgen-Dependent and -Independent Pathways in Prostate Carcinoma Cells
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076245
Abstract: The androgen-dependent or -independent pathways are regarded as primary therapeutic targets for the neoplasm of the prostate. Mucosa-associated lymphoid tissue 1 (MALT1) acting as a paracaspase in the regulation of nuclear factor κB (NF-κB) signal… read more here.
Keywords: dependent independent; independent pathways; androgen receptor; androgen ... See more keywords