Ubiquitin-Dependent and -Independent Roles of E3 Ligase RIPLET in Innate Immunity
Sign Up to like & getrecommendations! Published in 2019 at "Cell"
DOI: 10.1016/j.cell.2019.03.017
Abstract: The conventional view posits that E3 ligases function primarily through conjugating ubiquitin (Ub) to their substrate molecules. We report here that RIPLET, an essential E3 ligase in antiviral immunity, promotes the antiviral signaling activity of… read more here.
Keywords: immunity; rig; dependent independent; ubiquitin dependent ... See more keywords
Small Molecule Inhibits Metal-Dependent and -Independent Multifaceted Toxicity of Alzheimer's Disease.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.9b00216
Abstract: Alzheimer's disease (AD) is one of the most devastating forms of dementia, without reliable treatments to cure, delay the onset, or prevent the disease progression. The proposed toxic mechanisms of AD include amyloidogenesis of amyloid… read more here.
Keywords: multifaceted toxicity; alzheimer disease; dependent independent; toxicity ... See more keywords
Monosaccharides drive Salmonella gut colonization in a context-dependent or -independent manner
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-56890-y
Abstract: The carbohydrates that fuel gut colonization by S. Typhimurium are not fully known. To investigate this, we designed a quality-controlled mutant pool to probe the metabolic capabilities of this enteric pathogen. Using neutral genetic barcodes,… read more here.
Keywords: salmonella; context dependent; dependent independent; colonization ... See more keywords
Catalytic-dependent and -independent roles of TET3 in the regulation of specific genetic programs during neuroectoderm specification
Sign Up to like & getrecommendations! Published in 2024 at "Communications Biology"
DOI: 10.1038/s42003-024-06120-w
Abstract: The ten-eleven-translocation family of proteins (TET1/2/3) are epigenetic regulators of gene expression. They regulate genes by promoting DNA demethylation (i.e., catalytic activity) and by partnering with regulatory proteins (i.e., non-catalytic functions). Unlike Tet1 and Tet2,… read more here.
Keywords: independent roles; dependent independent; specification; catalytic dependent ... See more keywords
FDX1-dependent and independent mechanisms of elesclomol-mediated intracellular copper delivery
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2216722120
Abstract: Significance Genetic defects in copper transport to cuproenzymes result in infantile disorders for which no effective therapies are currently available. Recent studies have uncovered the therapeutic potential of elesclomol, a copper-transporting drug, in the treatment… read more here.
Keywords: dependent independent; copper; independent mechanisms; fdx1 dependent ... See more keywords
A mouse model to distinguish NLRP6-mediated inflammasome-dependent and -independent functions
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2321419121
Abstract: Significance NLRP6 is an IEC-specific NLR that senses microbial dsRNA and LTA, which mediates inflammasome and type I IFN activation and may regulate NF-κB and MAPK pathways. Previous studies used complete knock-out of NLRP6 in… read more here.
Keywords: inflammasome dependent; independent functions; nlrp6 mediated; mouse model ... See more keywords
The Chitosan Nanoparticle-based Adjuvant CH-100 Orchestrates Multifaceted Innate Immune Activation via STING-Dependent and -Independent Pathways.
Sign Up to like & getrecommendations! Published in 2025 at "International immunology"
DOI: 10.1093/intimm/dxaf054
Abstract: Adjuvants enhance vaccine efficacy by activating innate immunity, yet the mechanisms of nanoparticle-based adjuvants remain incompletely defined. Here, we characterize CH-100, a chitosan nanoparticle adjuvant, and its capacity to coordinate dendritic cell (DC) activation and… read more here.
Keywords: dependent independent; activation; sting dependent; nanoparticle based ... See more keywords
Illuminating stomatal responses to red light: establishing the role of Ci-dependent versus -independent mechanisms in control of stomatal behaviour
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Experimental Botany"
DOI: 10.1093/jxb/erae093
Abstract: Abstract The stomatal response to red light appears to link stomatal conductance (gs) with photosynthetic rates. Initially, it was suggested that changes in intercellular CO2 concentration (Ci) provide the main cue via a Ci-dependent response.… read more here.
Keywords: responses red; independent mechanisms; response; dependent independent ... See more keywords
The pVHL neglected functions, a tale of hypoxia-dependent and -independent regulations in cancer
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DOI: 10.1098/rsob.200109
Abstract: The von Hippel–Lindau protein (pVHL) is a tumour suppressor mainly known for its role as master regulator of hypoxia-inducible factor (HIF) activity. Functional inactivation of pVHL is causative of the von Hippel–Lindau disease, an inherited… read more here.
Keywords: pvhl; dependent independent; neglected functions; pvhl neglected ... See more keywords
β-Amyloid–Dependent and –Independent Genetic Pathways Regulating CSF Tau Biomarkers in Alzheimer Disease
Sign Up to like & getrecommendations! Published in 2022 at "Neurology"
DOI: 10.1212/wnl.0000000000200605
Abstract: Background and Objectives Abnormal metabolism of β-amyloid (Aβ) and soluble phosphorylated tau (P-tau), as well as neurodegeneration, are key components of Alzheimer disease (AD), but it is unclear how these different processes are related to… read more here.
Keywords: dependent independent; genetic pathways; tau; csf ... See more keywords
The role of activation of two different sGC binding sites by NO‐dependent and NO‐independent mechanisms in the regulation of SACs in rat ventricular cardiomyocytes
Sign Up to like & getrecommendations! Published in 2022 at "Physiological Reports"
DOI: 10.14814/phy2.15246
Abstract: The mechanoelectrical feedback (MEF) mechanism in the heart that plays a significant role in the occurrence of arrhythmias, involves cation flux through cation nonselective stretch‐activated channels (SACs). It is well known that nitric oxide (NO)… read more here.
Keywords: ventricular cardiomyocytes; dependent independent; cell; regulation ... See more keywords