The β and γ subunits play distinct functional roles in the α2βγ heterotetramer of human NAD-dependent isocitrate dehydrogenase
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DOI: 10.1038/srep41882
Abstract: Human NAD-dependent isocitrate dehydrogenase existing as the α2βγ heterotetramer, catalyzes the decarboxylation of isocitrate into α-ketoglutarate in the Krebs cycle, and is allosterically regulated by citrate, ADP and ATP. To explore the functional roles of… read more here.
Keywords: dependent isocitrate; human nad; nad dependent; isocitrate dehydrogenase ... See more keywords
Isocitrate protects DJ-1 null dopaminergic cells from oxidative stress through NADP+-dependent isocitrate dehydrogenase (IDH)
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DOI: 10.1371/journal.pgen.1006975
Abstract: DJ-1 is one of the causative genes for early onset familiar Parkinson’s disease (PD) and is also considered to influence the pathogenesis of sporadic PD. DJ-1 has various physiological functions which converge on controlling intracellular… read more here.
Keywords: dependent isocitrate; isocitrate; nadp dependent; idh ... See more keywords