Histamine Sensitization of the Voltage-Gated Sodium Channel Nav1.7 Contributes to Histaminergic Itch in Mice.
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DOI: 10.1021/acschemneuro.2c00012
Abstract: Itch, a common clinical symptom of many skin diseases, severely impairs the life quality of patients. Nav1.7, a subtype of voltage-gated sodium channels mainly expressed in primary sensory neurons, is responsible for the amplification of… read more here.
Keywords: voltage gated; histamine dependent; dependent itch; itch ... See more keywords
Anoctamin 1/TMEM16A in pruritoceptors is essential for Mas-related G protein receptor-dependent itch.
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DOI: 10.1097/j.pain.0000000000002611
Abstract: ABSTRACT Itch is an unpleasant sensation that evokes a desire to scratch. Pathologic conditions such as allergy or atopic dermatitis produce severe itching sensation. Mas-related G protein receptors (Mrgprs) are receptors for many endogenous pruritogens.… read more here.
Keywords: related protein; drg neurons; dependent itch; itch ... See more keywords