The cyclin‐dependent kinase inhibitor p27Kip1 interacts with the aryl hydrocarbon receptor and negatively regulates its transcriptional activity
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14434
Abstract: p27Kip1 functions to coordinate cell cycle progression through the inhibition of cyclin‐dependent kinase (CDK) complexes. p27Kip1 also exerts distinct activities beyond CDK‐inhibition, including functioning as a transcriptional regulator. The aryl hydrocarbon receptor (AhR) is a… read more here.
Keywords: hydrocarbon receptor; p27kip1; dependent kinase; cyclin dependent ... See more keywords
Cyclin‐dependent kinase 5 promotes the growth of tongue squamous cell carcinoma through the microRNA 513c‐5p/cell division cycle 25B pathway and is associated with a poor prognosis
Sign Up to like & getrecommendations! Published in 2022 at "Cancer"
DOI: 10.1002/cncr.34136
Abstract: The objective of this study was to investigate the role and molecular mechanism of cyclin‐dependent kinase 5 (CDK5) in regulating the growth of tongue squamous cell carcinoma (TSCC). read more here.
Keywords: cell; tongue squamous; dependent kinase; squamous cell ... See more keywords
Evaluation of Absolute Oral Bioavailability and Bioequivalence of Ribociclib, a Cyclin‐Dependent Kinase 4/6 Inhibitor, in Healthy Subjects
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.853
Abstract: Ribociclib, a selective and potent cyclin‐dependent kinase 4/6 inhibitor, has demonstrated safety and efficacy in combination with endocrine therapy in hormone receptor‐positive, human epidermal growth factor receptor‐2‐negative advanced breast cancer. In 2 open‐label crossover studies… read more here.
Keywords: bioequivalence; cyclin dependent; bioavailability; kinase inhibitor ... See more keywords
The oral Ca/calmodulin‐dependent kinase II inhibitor RA608 improves contractile function and prevents arrhythmias in heart failure
Sign Up to like & getrecommendations! Published in 2020 at "ESC Heart Failure"
DOI: 10.1002/ehf2.12895
Abstract: Excessive activation of Ca/calmodulin‐dependent kinase II (CaMKII) is of critical importance in heart failure (HF) and atrial fibrillation. Unfortunately, lack of selectivity, specificity, and bioavailability have slowed down development of inhibitors for clinical use. We… read more here.
Keywords: heart; calmodulin dependent; heart failure; inhibitor ra608 ... See more keywords
Cyclin‐dependent kinase 7 contributes to myelin maintenance in the adult central nervous system and promotes myelin gene expression
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DOI: 10.1002/glia.24186
Abstract: Mechanisms regulating oligodendrocyte differentiation, developmental myelination and myelin maintenance in adulthood are complex and still not completely described. Their understanding is crucial for the development of new protective or therapeutic strategies in demyelinating pathologies such… read more here.
Keywords: myelination; dependent kinase; myelin maintenance; cyclin dependent ... See more keywords
Inhibited histone deacetylase 3 ameliorates myocardial ischemia–reperfusion injury in a rat model by elevating microRNA‐19a‐3p and reducing cyclin‐dependent kinase 2
Sign Up to like & getrecommendations! Published in 2020 at "IUBMB Life"
DOI: 10.1002/iub.2402
Abstract: Over the years, the roles of microRNAs (miRNAs) and histone deacetylase 3 (HDAC3) in human diseases have been investigated. This study focused on the effect of miR‐19a‐3p and HDAC3 in myocardial ischemia–reperfusion (I/R) injury (MIRI)… read more here.
Keywords: cyclin dependent; myocardial ischemia; histone deacetylase; dependent kinase ... See more keywords
Cyclin‐dependent kinase 7 is essential for spermatogenesis by regulating retinoic acid signaling pathways and the STAT3 molecular pathway
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DOI: 10.1002/iub.2574
Abstract: Spermatogenesis is a complex process that requires precise regulation. Phosphorylation plays a role in spermatogenesis by regulating protein structure and activity. This study focused on cyclin‐dependent kinase 7 (CDK7), and explored its function and molecular… read more here.
Keywords: spermatogenesis; cdk7; cyclin dependent; dependent kinase ... See more keywords
Gene polymorphisms of cyclin‐dependent kinase inhibitor and matrix metalloproteinase‐9 in Sudanese patients with esophageal squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.2074
Abstract: The polymorphisms of the cyclin‐dependent kinase inhibitor (CDKN1A) gene and matrix metalloproteinase‐9 (MMP9) gene may increase one's susceptibility to malignancies. In this study, the association of the single nucleotide polymorphisms (SNPs) CDKN1A rs1059234 c.70C>T at… read more here.
Keywords: dependent kinase; cyclin dependent; kinase inhibitor; gene ... See more keywords
Antitumor effects of flavopiridol, a cyclin-dependent kinase inhibitor, on human cholangiocarcinoma in vitro and in an in vivo xenograft model
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DOI: 10.1016/j.heliyon.2019.e01675
Abstract: Flavopiridol, a pan-cyclin-dependent kinase (CDK) inhibitor, was recently identified as an effective antitumor agent for several cancers. We investigated the antitumor effect of flavopiridol on cholangiocarcinoma (CCA), in vitro and in vivo. A methylthiotetrazole assay… read more here.
Keywords: flavopiridol; cyclin dependent; vitro vivo; xenograft model ... See more keywords
Reaction-Based Enumeration, Active Learning, and Free Energy Calculations To Rapidly Explore Synthetically Tractable Chemical Space and Optimize Potency of Cyclin-Dependent Kinase 2 Inhibitors
Sign Up to like & getrecommendations! Published in 2019 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.9b00367
Abstract: The hit-to-lead and lead optimization processes usually involve the design, synthesis, and profiling of thousands of analogs prior to clinical candidate nomination. A hit finding campaign may begin with a virtual screen that explores millions… read more here.
Keywords: active learning; cyclin dependent; chemical space; dependent kinase ... See more keywords
Screening through Lead Optimization of High Affinity, Allosteric Cyclin-Dependent Kinase 2 (CDK2) Inhibitors as Male Contraceptives That Reduce Sperm Counts in Mice.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01731
Abstract: Although cyclin-dependent kinase 2 (CDK2) is a validated target for both cancer and contraception, developing a CDK2 inhibitor with exquisite selectivity has been challenging due to the structural similarity of the ATP-binding site, where most… read more here.
Keywords: cdk2; dependent kinase; affinity; cyclin dependent ... See more keywords