T‐17, a novel cyclin‐dependent kinases/histone deacetylases dual inhibitor, induces cancer cells death through cell cycle arrest and apoptosis
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21977
Abstract: Combination of cyclin‐dependent kinases (CDKs) and histone deacetylases (HDACs) inhibitors may have statistical synergy in suppressing cancer cell proliferation. Herein, a novel CDKs/HDACs dual inhibitor T‐17 was rationally designed, synthesized, and evaluated. Our results demonstrated… read more here.
Keywords: cell; dual inhibitor; cyclin dependent; histone deacetylases ... See more keywords
A curious case of cyclin‐dependent kinases in neutrophils
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.2ru1021-573r
Abstract: Neutrophils are terminally differentiated, short‐lived white blood cells critical for innate immunity. Although cyclin‐dependent kinases (CDKs) are typically related to cell cycle progression, increasing evidence has shown that they regulate essential functions of neutrophils. This… read more here.
Keywords: case cyclin; cycle; curious case; kinases neutrophils ... See more keywords
When cyclin‐dependent kinases meet viral infections, including SARS‐CoV‐2
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27719
Abstract: Cyclin‐dependent kinases (CDKs) are protein kinases that play a key role in cell division and transcriptional regulation. Recent studies have demonstrated the critical roles of CDKs in various viral infections. However, the molecular processes underpinning… read more here.
Keywords: viral infections; cyclin dependent; dependent kinases; kinases meet ... See more keywords
Inhibition of cyclin-dependent kinases by AT7519 enhances nasopharyngeal carcinoma cell response to chemotherapy
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-020-04068-2
Abstract: Background The poor outcomes in nasopharyngeal carcinoma (NPC) necessitate new treatments. AT7519 is a potent inhibitor of several cyclin-dependent kinases (CDKs) and is currently in the early phase of clinical development for cancer treatment. The… read more here.
Keywords: dependent kinases; nasopharyngeal carcinoma; cell; cyclin dependent ... See more keywords
Cyclin-dependent Kinases 4/6 Inhibitors in Neuroendocrine Neoplasms: from Bench to Bedside
Sign Up to like & getrecommendations! Published in 2022 at "Current Oncology Reports"
DOI: 10.1007/s11912-022-01251-x
Abstract: Cyclin-dependent kinases (CDKs) are key regulators that play an important role in cell division. Palbociclib, ribociclib and abemaciclib showed significant antitumor activity in several malignancies and, recently, also a myeloprotective effect for trilaciclib when added… read more here.
Keywords: neuroendocrine neoplasms; dependent kinases; cdk4 inhibitors; inhibitors neuroendocrine ... See more keywords
Cyclins, Cyclin-Dependent Kinases, and Cyclin-Dependent Kinase Inhibitors in the Mouse Nervous System
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Neurobiology"
DOI: 10.1007/s12035-020-01958-7
Abstract: Development and normal physiology of the nervous system require proliferation and differentiation of stem and progenitor cells in a strictly controlled manner. The number of cells generated depends on the type of cell division, the… read more here.
Keywords: dependent kinases; cyclin dependent; nervous system; cyclins cyclin ... See more keywords
An analysis of available biomarker data for targeting cyclin-dependent kinases 4 and 6 (CDK4/6) in breast cancer
Sign Up to like & getrecommendations! Published in 2019 at "Expert Review of Precision Medicine and Drug Development"
DOI: 10.1080/23808993.2019.1604136
Abstract: ABSTRACT Introduction: Inhibitors of cyclin-dependent kinases 4 and 6 (CDK4/6i) are a standard of care for advanced estrogen receptor (ER)–positive breast cancer in combination with hormonal therapy. Recent data from large trials comprising these agents… read more here.
Keywords: dependent kinases; kinases cdk4; cyclin dependent; breast cancer ... See more keywords
Calcium/Calmodulin-Dependent Kinases in the Hypothalamus, Pituitary, and Pineal Gland: An Overview
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Endocrinology"
DOI: 10.1155/2022/1103346
Abstract: We review the literature on the little-known roles of specific CaMKs in regulating endocrine functions of the pineal gland, the pituitary gland, and the hypothalamus. Melatonin activates hippocampal CaMKII, which then influences dendritogenesis. In the… read more here.
Keywords: calmodulin dependent; kinases hypothalamus; pineal gland; gland ... See more keywords
Abstract P5-05-14: Cyclin-dependent kinases inhibitors improve antimetabolite drug potency depending on SAMHD1 expression
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs19-p5-05-14
Abstract: Introduction Cyclin-dependent kinase (CDK) 4/6 inhibitors represent a new paradigm in the treatment of hormone receptor (HR) positive and HER-2 negative metastatic breast cancer (MBC). However, despite their evident clinical benefit, the cellular and molecular… read more here.
Keywords: cyclin dependent; dependent kinases; drug; cyclin ... See more keywords
Cyclin-dependent kinases and CDK inhibitors in virus-associated cancers
Sign Up to like & getrecommendations! Published in 2020 at "Infectious Agents and Cancer"
DOI: 10.1186/s13027-020-00295-7
Abstract: The role of several risk factors, such as pollution, consumption of alcohol, age, sex and obesity in cancer progression is undeniable. Human malignancies are mainly characterized by deregulation of cyclin-dependent kinases (CDK) and cyclin inhibitor… read more here.
Keywords: kinases cdk; cdk inhibitors; dependent kinases; cyclin dependent ... See more keywords
Cyclin-dependent kinases 4 and 6 inhibitors in HR+/HER2- advanced breast cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.e13048
Abstract: e13048Background: In a previous meta-analysis which published in 23rd NCCN Annual Conference, we reported that the addition of cyclin-dependent kinases 4 and 6 inhibitors (CDKi) to endocrine therapy (ET) improved progression-free survival (PFS) for patients… read more here.
Keywords: dependent kinases; cyclin dependent; breast cancer; advanced breast ... See more keywords