Fusobacterium nucleatum promotes M2 polarization of macrophages in the microenvironment of colorectal tumours via a TLR4-dependent mechanism
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-018-2233-x
Abstract: Fusobacterium nucleatum (Fn) has been shown to promote colorectal cancer (CRC) development by inhibiting host anti-tumour immunity. However, the impact of Fn infection on macrophage polarization and subsequent intestinal tumour formation as well as the… read more here.
Keywords: tlr4 dependent; polarization macrophages; infection; dependent mechanism ... See more keywords
Activation of YAP regulates muscle fiber size in a PKC-dependent mechanism during chick in vitro myogenesis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of muscle research and cell motility"
DOI: 10.1007/s10974-021-09608-8
Abstract: The formation of skeletal muscle fibers is an intricate process controlled by a multitude of signaling pathways, including Wnt, Shh, and FGF. However, the role of the Hippo pathway during vertebrate myofiber formation has conflicting… read more here.
Keywords: muscle; dependent mechanism; pkc dependent; yap ... See more keywords
Post-ischemic reperfusion with diosmin attenuates myocardial injury through a nitric oxidase synthase-dependent mechanism.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.118188
Abstract: Abstract Aims Diosmin is a citrus flavonoid with broad biological activities. Moreover, the administration of biologically active compounds during the myocardial reperfusion potentiates the cardioprotection and survival rate. Hence, this study aimed to evaluate whether… read more here.
Keywords: synthase; reperfusion diosmin; dependent mechanism; reperfusion ... See more keywords
Membrane-Dependent Binding and Entry Mechanism of Dopamine into Its Receptor
Sign Up to like & getrecommendations! Published in 2020 at "ACS Chemical Neuroscience"
DOI: 10.1021/acschemneuro.9b00656
Abstract: Synaptic neurotransmission has recently been proposed to function via either a membrane-independent or a membrane-dependent mechanism, depending on the neurotransmitter type. In the membrane-dependent mechanism, amphipathic neurotransmitters first partition to the lipid headgroup region and… read more here.
Keywords: mechanism; dependent mechanism; entry; receptor ... See more keywords
Hypoxia-induced angiotensin II by the lactate-chymase-dependent mechanism mediates radioresistance of hypoxic tumor cells
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep42396
Abstract: The renin-angiotensin system (RAS) is a principal determinant of arterial blood pressure and fluid and electrolyte balance. RAS component dysregulation was recently found in some malignancies and correlated with poor patient outcomes. However, the exact… read more here.
Keywords: chymase dependent; tumor cells; dependent mechanism; angiotensin ... See more keywords
Structure-Dependent Mechanism of Single-atom Cobalt on Macroporous Carbon Nitride in (Photo-)Fenton-Like Reactions
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Materials Chemistry A"
DOI: 10.1039/d3ta01926h
Abstract: Single-atom catalysts have been believed as ideal materials for achieving maximum utilization of the metal active sites in Fenton-like catalysis for eliminating organic pollutants. However, the relationship between single-atom structure... read more here.
Keywords: atom; single atom; structure dependent; fenton like ... See more keywords
Vertical sleeve gastrectomy improves ventilatory drive through a leptin-dependent mechanism.
Sign Up to like & getrecommendations! Published in 2019 at "JCI insight"
DOI: 10.1172/jci.insight.124469
Abstract: Obesity hypoventilation syndrome (OHS) is a serious disorder characterized by daytime hypercapnia, disordered breathing, and a reduction in chemosensitivity. Vertical sleeve gastrectomy (VSG), a bariatric surgical procedure resulting in weight loss and weight-independent improvements in… read more here.
Keywords: vertical sleeve; leptin dependent; leptin; dependent mechanism ... See more keywords
JAML promotes acute kidney injury mainly through a macrophage-dependent mechanism
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.158571
Abstract: Although macrophages are undoubtedly attractive therapeutic targets for acute kidney injury (AKI) because of their critical roles in renal inflammation and repair, the underlying mechanisms of macrophage phenotype switching and efferocytosis in the regulation of… read more here.
Keywords: acute kidney; jaml; injury; macrophage ... See more keywords
An NFκB-dependent mechanism of tumor cell plasticity and lateral transmission of aggressive features
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.25465
Abstract: Breast cancer is a complex disease exhibiting extensive inter- and intra-tumor heterogeneity. Inflammation is a well-known driver of cancer progression, often attributed to immune cells infiltrating the tumor stroma. However, tumor cells themselves are capable… read more here.
Keywords: dependent mechanism; tumor cell; cancer; cell ... See more keywords
Indomethacin Disrupts the Formation of β-Amyloid Plaques via an α2-Macroglobulin-Activating lrp1-Dependent Mechanism
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22158185
Abstract: Epidemiological studies have implied that the nonsteroidal anti-inflammatory drug (NSAID) indomethacin slows the development and progression of Alzheimer’s disease (AD). However, the underlying mechanisms are notably understudied. Using a chimeric mouse/human amyloid precursor protein (Mo/HuAPP695swe)… read more here.
Keywords: disrupts formation; formation amyloid; dependent mechanism; indomethacin ... See more keywords