Protective effects of metformin in various cardiovascular diseases: Clinical evidence and AMPK‐dependent mechanisms
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17519
Abstract: Metformin, a well‐known AMPK agonist, has been widely used as the first‐line drug for treating type 2 diabetes. There had been a significant concern regarding the use of metformin in people with cardiovascular diseases (CVDs)… read more here.
Keywords: dependent mechanisms; clinical evidence; ampk dependent; cardiovascular diseases ... See more keywords
Complement-Dependent Mechanisms and Interventions in Periodontal Disease
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.00406
Abstract: Periodontitis is a prevalent inflammatory disease that leads to the destruction of the tooth-supporting tissues. Current therapies are not effective for all patients and this oral disease continues to be a significant public health and… read more here.
Keywords: periodontal disease; dependent mechanisms; complement dependent; mechanisms interventions ... See more keywords
pH-Dependent Mechanisms of Influenza Infection Mediated by Hemagglutinin
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2021.777095
Abstract: Influenza hemagglutinin (HA) is a viral membrane bound protein that plays a critical role in the viral life cycle by mediating entry into target cells. HA exploits the lowering of the pH in the endosomal… read more here.
Keywords: infection mediated; infection; mechanisms influenza; dependent mechanisms ... See more keywords
Chaperone-Dependent Mechanisms as a Pharmacological Target for Neuroprotection
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DOI: 10.3390/ijms24010823
Abstract: Modern pharmacotherapy of neurodegenerative diseases is predominantly symptomatic and does not allow vicious circles causing disease development to break. Protein misfolding is considered the most important pathogenetic factor of neurodegenerative diseases. Physiological mechanisms related to… read more here.
Keywords: neuroprotection; dependent mechanisms; disease; mechanisms pharmacological ... See more keywords
Chloride-dependent mechanisms of multimodal sensory discrimination and nociceptive sensitization in Drosophila
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DOI: 10.7554/elife.76863
Abstract: Individual sensory neurons can be tuned to many stimuli, each driving unique, stimulus-relevant behaviors, and the ability of multimodal nociceptor neurons to discriminate between potentially harmful and innocuous stimuli is broadly important for organismal survival.… read more here.
Keywords: dependent mechanisms; chloride dependent; sensitization; drosophila ... See more keywords