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Published in 2020 at "Gastric Cancer"
DOI: 10.1007/s10120-020-01139-4
Abstract: Despite the promising preclinical antitumor activity of MET-targeting therapies, most clinical trials have failed. We introduced a new concept of quantitation of stroma-induced hepatocyte growth factor (HGF) to assess the actual MET signalling activity in…
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Keywords:
gastric cancer;
ligand dependent;
met signalling;
signalling activation ... See more keywords
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Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22179240
Abstract: NK1, a splicing variant of hepatocyte growth factor (HGF), binds to and activates Met receptor by forming an NK1 dimer and 2:2 complex with Met. Although the structural mechanism underlying Met activation by HGF remains…
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Keywords:
nk1;
dimer;
hgf;
activation ... See more keywords