Engineered Bacterial Flavin‐Dependent Monooxygenases for the Regiospecific Hydroxylation of Polycyclic Phenols
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DOI: 10.1002/cbic.202100480
Abstract: 4‐Hydroxyphenylacetate 3‐hydroxylase (4HPA3H), a flavin‐dependent monooxygenase from E. coli that catalyzes the hydroxylation of monophenols to catechols, was modified by rational redesign to convert also more bulky substrates, especially phenolic natural products like phenylpropanoids, flavones… read more here.
Keywords: flavin dependent; monooxygenases regiospecific; bacterial flavin; dependent monooxygenases ... See more keywords
Crystal Structures of Putative Flavin Dependent Monooxygenase from Alicyclobacillus Acidocaldarius
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DOI: 10.3390/cryst9110548
Abstract: Flavin dependent monooxygenases catalyze various reactions to play a key role in biological processes, such as catabolism, detoxification, and biosynthesis. Group D flavin dependent monooxygenases are enzymes with an Acyl-CoA dehydrogenase (ACAD) fold and use… read more here.
Keywords: putative flavin; flavin dependent; structures putative; alicyclobacillus acidocaldarius ... See more keywords
Properties and Mechanisms of Flavin-Dependent Monooxygenases and Their Applications in Natural Product Synthesis
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DOI: 10.3390/ijms23052622
Abstract: Natural products are usually highly complicated organic molecules with special scaffolds, and they are an important resource in medicine. Natural products with complicated structures are produced by enzymes, and this is still a challenging research… read more here.
Keywords: flavin dependent; mechanisms flavin; natural products; dependent monooxygenases ... See more keywords