Rational Engineering of the Nonheme Iron- and 2-Oxoglutarate-Dependent Oxygenase SptF.
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DOI: 10.1021/acs.orglett.2c00409
Abstract: The Fe- and 2-oxoglutarate-dependent oxygenase SptF is a promising powerful biocatalys with unusual catalytic versatility and promiscuity. The site-specific random substitution of N150, I63, and N65, which are involved in substrate interactions, generated three compounds… read more here.
Keywords: engineering; dependent oxygenase; oxoglutarate dependent; oxygenase sptf ... See more keywords
Stereoselectivity and Substrate Specificity of the Fe(II)/α-Ketoglutarate-Dependent Oxygenase TqaL.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c08116
Abstract: Non-heme iron enzymes are versatile catalysts in the biosynthesis of medicinal natural products and have attracted increasing attention as practical catalytic tools in chemical synthesis due to their ability to perform chemically challenging transformations. The… read more here.
Keywords: substrate specificity; ketoglutarate dependent; tqal; dependent oxygenase ... See more keywords