Biosynthesis of unique natural product scaffolds by Fe(II)/αKG-dependent oxygenases
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Natural Medicines"
DOI: 10.1007/s11418-025-01880-z
Abstract: Fe(II)/αKG-dependent oxygenases are multifunctional oxidases responsible for the formation of unique natural product skeletons. Studies of these enzymes are important because the knowledge of their catalytic functions, enzyme structures, and reaction mechanisms can be used… read more here.
Keywords: unique natural; biosynthesis unique; natural product; dependent oxygenases ... See more keywords
Role of Structural Dynamics in Selectivity and Mechanism of Non-heme Fe(II) and 2-Oxoglutarate-Dependent Oxygenases Involved in DNA Repair
Sign Up to like & getrecommendations! Published in 2020 at "ACS Central Science"
DOI: 10.1021/acscentsci.0c00312
Abstract: AlkB and its human homologue AlkBH2 are Fe(II)- and 2-oxoglutarate (2OG)-dependent oxygenases that repair alkylated DNA bases occurring as a consequence of reactions with mutagenic agents. We used molecular dynamics (MD) and combined quantum mechanics/molecular… read more here.
Keywords: dependent oxygenases; alkbh2; structural dynamics; repair ... See more keywords