FOXP4 inhibits squamous differentiation of atypical cells in cervical intraepithelial neoplasia via an ELF3‐dependent pathway
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DOI: 10.1111/cas.15489
Abstract: Although the human papillomavirus (HPV) vaccine is effective for preventing cervical cancers, this vaccine does not eliminate pre‐existing infections, and alternative strategies have been warranted. Here, we report that FOXP4 is a new target molecule… read more here.
Keywords: via elf3; elf3 dependent; squamous differentiation; differentiation ... See more keywords
Methane Production by Facultative Anaerobic Wood-Rot Fungi via a New Halomethane-Dependent Pathway
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DOI: 10.1128/spectrum.01700-22
Abstract: Here, we demonstrate that wood-rot fungi produce methane anaerobically without the involvement of methanogenic archaea via a new, halomethane-dependent pathway. These findings of an anaerobic fungal methane formation pathway open another avenue in methane research… read more here.
Keywords: halomethane dependent; rot fungi; methane; dependent pathway ... See more keywords
Plasticity in the Absence of NOTCH Uncovers a RUNX2-Dependent Pathway in Small Cell Lung Cancer
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DOI: 10.1158/0008-5472.can-21-1991
Abstract: A genetically engineered mouse model of NOTCH-mutant SCLC reveals that nonneuroendocrine plasticity persists in the absence of NOTCH, driven by a RUNX2-REST–dependent pathway and innate immune signaling. Neuroendocrine to nonneuroendocrine plasticity supports small cell lung… read more here.
Keywords: notch; nonneuroendocrine plasticity; dependent pathway; plasticity ... See more keywords
Involvement of the cAMP-Dependent Pathway in Dextromethorphan-Induced Inhibition of Spontaneous Glutamate Transmission in the Nucleus Tractus Solitarius Neurons of Guinea Pigs
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DOI: 10.1159/000495295
Abstract: Dextromethorphan (DEX) presynaptically decreases glutamatergic transmission in second-order neurons of the nucleus tractus solitarius (TS). To clarify the inhibitory mechanism of DEX, the present study examined the interaction of DEX with cAMP. The effects of… read more here.
Keywords: camp; dex; dependent pathway; nucleus tractus ... See more keywords
Oxidized LDL‐dependent pathway as new pathogenic trigger in arrhythmogenic cardiomyopathy
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DOI: 10.15252/emmm.202114365
Abstract: Arrhythmogenic cardiomyopathy (ACM) is hallmarked by ventricular fibro‐adipogenic alterations, contributing to cardiac dysfunctions and arrhythmias. Although genetically determined (e.g., PKP2 mutations), ACM phenotypes are highly variable. More data on phenotype modulators, clinical prognosticators, and etiological… read more here.
Keywords: oxidized ldl; dependent pathway; pathway new; ldl dependent ... See more keywords
Can TRIF/TICAM-1 Dependent Pathway be Target Pathway in Lumbar Intervertebral Disc Degeneration?
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DOI: 10.2139/ssrn.4178893
Abstract: AIM The current study aims to elucidate the role of the TIR-domain-containing adaptor-inducing interferon-β (TRIF) dependent pathway in intervertebral disc degeneration (IVD). MATERIAL AND METHODS 88 adult male patients with low back pain (LBP) (+/-… read more here.
Keywords: lumbar intervertebral; disc degeneration; intervertebral disc; dependent pathway ... See more keywords
Role of the MyD88 Dependent Pathway in Degenerative Disc Disease.
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DOI: 10.5137/1019-5149.jtn.42017-22.2
Abstract: AIM We aim to define the substantial role of the TLR4 signaling pathway in the MyD88-dependent pathway and evaluate the results of TLR4 activation in nucleus pulposus cells. Moreover, we aim to associate this pathway… read more here.
Keywords: degeneration; role; myd88 dependent; dependent pathway ... See more keywords