An NMR portrait of functional and dysfunctional allosteric cooperativity in cAMP‐dependent protein kinase A
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Letters"
DOI: 10.1002/1873-3468.14610
Abstract: The cAMP‐dependent protein kinase A (PKA) is the archetypical eukaryotic kinase. The catalytic subunit (PKA‐C) structure is highly conserved among the AGC‐kinase family. PKA‐C is a bilobal enzyme with a dynamic N‐lobe, harbouring the Adenosine‐5′‐triphosphate… read more here.
Keywords: cooperativity; protein kinase; kinase; camp dependent ... See more keywords
Characterization of Competitive Inhibitors of Plasmodium falciparum cGMP‐Dependent Protein Kinase **
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202100704
Abstract: Plasmodium falciparum cGMP‐dependent protein kinase (PfPKG) is an enticing antimalarial drug target. Novel chemotypes are needed because existing inhibitors have safety issues that may prevent further development. This work demonstrates isoxazole‐based compounds are potent ATP… read more here.
Keywords: plasmodium falciparum; protein kinase; competitive inhibitors; falciparum cgmp ... See more keywords
Ca2+/calmodulin‐dependent protein kinase II and protein kinase G oxidation contributes to impaired sarcomeric proteins in hypertrophy model
Sign Up to like & getrecommendations! Published in 2022 at "ESC Heart Failure"
DOI: 10.1002/ehf2.13973
Abstract: Volume overload (VO) induced hypertrophy is one of the hallmarks to the development of heart diseases. Understanding the compensatory mechanisms involved in this process might help preventing the disease progression. read more here.
Keywords: ca2 calmodulin; protein kinase; calmodulin dependent; dependent protein ... See more keywords
Targeted and systemic insights into the crosstalk between DNA-dependent protein kinase catalytic subunit and receptors of estrogen, progesterone and epidermal growth factor in the context of cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular biology reports"
DOI: 10.1007/s11033-021-06797-w
Abstract: DNA-dependent protein kinase catalytic subunit (DNA-PKcs) has emerged as a regulator of carcinogenesis. Increased expression of DNA-PKcs correlates with metastatic cancers. Here we review recently reported crosstalk of DNA-PKcs with estrogen (ER), progesterone (PR) and… read more here.
Keywords: dna dependent; dna; dna pkcs; dependent protein ... See more keywords
Activation of a calcium-dependent protein kinase involved in the Azospirillum growth promotion in rice
Sign Up to like & getrecommendations! Published in 2017 at "World Journal of Microbiology and Biotechnology"
DOI: 10.1007/s11274-016-2186-1
Abstract: Rice seedlings (Oryza sativa) inoculated with the plant growth-promoting rhizobacteria Azospirillum brasilense FT326 showed an enhanced development of the root system 3 days after inoculation. Later on, a remarkable enlargement of shoots was also evident. An… read more here.
Keywords: rice; kinase; dependent protein; protein kinase ... See more keywords
Autoactivation of C-terminally truncated Ca2+/calmodulin-dependent protein kinase (CaMK) Iδ via CaMK kinase-independent autophosphorylation.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2019.05.004
Abstract: Ca2+/calmodulin-dependent protein kinase I isoforms (CaMKIα, β, γ, and δ) play important roles in Ca2+ signaling in eukaryotic cells by being activated by CaMK kinase (CaMKK) through phosphorylation at a Thr residue in the activation… read more here.
Keywords: ca2 calmodulin; calmodulin dependent; kinase; camki ... See more keywords
cAMP-dependent protein kinase regulates secretion of apical membrane antigen 1 (AMA1) in Plasmodium yoelii.
Sign Up to like & getrecommendations! Published in 2021 at "Parasitology international"
DOI: 10.1016/j.parint.2021.102435
Abstract: Malaria remains a heavy global burden on human health, and it is important to understand the molecular and cellular biology of the parasite to find targets for drug and vaccine development. The mouse malaria model… read more here.
Keywords: camp dependent; dependent protein; yoelii; plasmodium yoelii ... See more keywords
The calcium-dependent protein kinase 1 from Toxoplasma gondii as target for structure-based drug design
Sign Up to like & getrecommendations! Published in 2017 at "Parasitology"
DOI: 10.1017/s0031182017001901
Abstract: Summary The apicomplexan protozoan parasites include the causative agents of animal and human diseases ranging from malaria (Plasmodium spp.) to toxoplasmosis (Toxoplasma gondii). The complex life cycle of T. gondii is regulated by a unique… read more here.
Keywords: calcium dependent; dependent protein; gondii; structure based ... See more keywords
Molecular Insights into the Regulation of 3-Phosphoinositide-Dependent Protein Kinase 1: Modeling the Interaction between the Kinase and the Pleckstrin Homology Domains
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c02020
Abstract: The 3-phosphoinositide-dependent protein kinase 1 (PDK1) K465E mutant kinase can still activate protein kinase B (PKB) at the membrane in a phosphatidylinositol-3,4,5-trisphosphate (PIP3, PtdIns(3,4,5)P3) independent manner. To understand this new PDK1 regulatory mechanism, docking and… read more here.
Keywords: protein kinase; pdk1; kinase; dependent protein ... See more keywords
Hydralazine targets cAMP-dependent protein kinase leading to sirtuin1/5 activation and lifespan extension in C. elegans
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-12425-w
Abstract: Therapeutic activation of mitochondrial function has been suggested as an effective strategy to combat aging. Hydralazine is an FDA-approved drug used in the treatment of hypertension, heart failure and cancer. Hydralazine has been recently shown… read more here.
Keywords: camp dependent; dependent protein; lifespan; activation ... See more keywords
Highly effective identification of drug targets at the proteome level by pH-dependent protein precipitation
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d2sc03326g
Abstract: Fully understanding the target spaces of drugs is essential for investigating the mechanism of drug action and side effects, as well as for drug discovery and repurposing. In this study, we present an energetics-based approach,… read more here.
Keywords: protein precipitation; identification; dependent protein; target proteins ... See more keywords