Gossypol Broadly Inhibits Coronaviruses by Targeting RNA‐Dependent RNA Polymerases (Adv. Sci. 35/2022)
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DOI: 10.1002/advs.202203499
Abstract: Outbreaks of coronaviruses (CoVs), especially severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), have posed serious threats to humans and animals, which urgently calls for effective broad‐spectrum antivirals. RNA‐dependent RNA polymerase (RdRp) plays an essential role… read more here.
Keywords: dependent rna; gossypol broadly; coronavirus; rna dependent ... See more keywords
A computational comparative analysis of the binding mechanism of molnupiravir's active metabolite to RNA‐dependent RNA polymerase of wild‐type and Delta subvariant AY.4 of SARS‐CoV‐2
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DOI: 10.1002/jcb.30226
Abstract: The antiviral drug molnupiravir targets the SARS‐CoV‐2 RNA‐dependent RNA polymerase (RdRP) enzyme. Early treatment with molnupiravir reduced the risk of hospitalization or death in at‐risk, unvaccinated adults with COVID‐19, according to phase 3 clinical trials.… read more here.
Keywords: dependent rna; rna polymerase; rdrp; rna ... See more keywords
Drug repurposing toward the inhibition of RNA‐dependent RNA polymerase of various flaviviruses through computational study
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DOI: 10.1002/jcb.30352
Abstract: Numerous pathogens affecting human is present in the flavivirus family namely west nile, dengue, yellow fever, and zika which involves in development of global burden and distressing the environment economically. Till date, no approved drugs… read more here.
Keywords: rna dependent; dependent rna; rna polymerase; inhibition ... See more keywords
Drug repurposing for Mpox: Discovery of small molecules as potential inhibitors against DNA‐dependent RNA polymerase using molecular modeling approach
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DOI: 10.1002/jcb.30397
Abstract: Mpox (formerly Monkeypox), a zoonotic illness caused by the Mpox virus, belongs to the Orthopoxvirus genus in the family Poxviridae. To design and develop effective antiviral therapeutics against DNA viruses, the DNA‐dependent RNA polymerase (DdRp)… read more here.
Keywords: dependent rna; rna polymerase; kcal mol; dna dependent ... See more keywords
Corrigendum to: The potential chemical structure of anti-SARS-CoV-2 RNA-dependent RNA polymerase (Journal of Medical Virology, (2020), 92, 6, (693-697), 10.1002/jmv.25761)
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DOI: 10.1002/jmv.26176
Abstract: The potential chemical structure of anti-SARS-CoV-2 RNA-dependent RNA polymerase. The article to which this Corrigendum refers was published in Journal of Medical Virology 92(6): 693 to 697 (https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.25761). The corrigendum corrects protease to polymerase in… read more here.
Keywords: dependent rna; rna dependent; rna polymerase; rna ... See more keywords
Discovery of Potent Non-nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from Fragment Screening and Structure-Guided Design.
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DOI: 10.1007/978-981-10-8727-1_14
Abstract: Flavivirus NS5 RNA-dependent RNA polymerase (RdRp) is an important drug target. Whilst a number of allosteric inhibitors have been described for Hepatitis C virus RdRp, few have been described for DENV RdRp. In addition, compound… read more here.
Keywords: rna dependent; rna; structure guided; rna polymerase ... See more keywords
Repurposing nonnucleoside antivirals against SARS-CoV2 NSP12 (RNA dependent RNA polymerase): In silico-molecular insight
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DOI: 10.1016/j.bbrc.2021.07.050
Abstract: The pandemic of SARS-CoV-2 has necessitated expedited research efforts towards finding potential antiviral targets and drug development measures. While new drug discovery is time consuming, drug repurposing has been a promising area for elaborate virtual… read more here.
Keywords: rdrp; rna dependent; rna; rna polymerase ... See more keywords
Lipopeptides against COVID-19 RNA-dependent RNA polymerase using molecular docking
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DOI: 10.1016/j.bj.2021.11.010
Abstract: Aims Coronavirus disease 2019 (COVID-19) is caused by a novel virus that is responsible for the largest pandemic in recent times. Although numerous studies have explored methods to cope with COVID-19 and targeted drugs and… read more here.
Keywords: rna polymerase; molecular docking; dependent rna; rna dependent ... See more keywords
Remdesivir Is Effective in Combating COVID-19 because It Is a Better Substrate than ATP for the Viral RNA-Dependent RNA Polymerase
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DOI: 10.1016/j.isci.2020.101849
Abstract: COVID-19 is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is currently being treated using Remdesivir, a nucleoside analog that inhibits the RNA-dependent-RNA polymerase (RdRp). However, the enzymatic mechanism and efficiency of… read more here.
Keywords: rna dependent; rna; rna polymerase; covid ... See more keywords
Surface plasmon resonance approach to study drug interactions with SARS-CoV-2 RNA-dependent RNA polymerase highlights treatment potential of suramin
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DOI: 10.1016/j.jviromet.2021.114283
Abstract: The SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) is essential for virus replication, therefore it is a promising drug target. Here we present a surface plasmon resonance approach to study the interaction of RdRp with drugs in… read more here.
Keywords: cov rna; rna dependent; rna polymerase; suramin ... See more keywords
RdRp (RNA-dependent RNA polymerase): A key target providing anti-virals for the management of various viral diseases
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DOI: 10.1016/j.molstruc.2021.131756
Abstract: With the arrival of the Covid-19 pandemic, anti-viral agents have regained center stage in the arena of medicine. Out of the various drug targets involved in managing RNA-viral infections, the one that dominates almost all… read more here.
Keywords: rna dependent; rna polymerase; various viral; dependent rna ... See more keywords