Isobavachalcone suppresses the TRIF‐dependent signaling pathway of Toll‐like receptors
Sign Up to like & getrecommendations! Published in 2021 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202100404
Abstract: Toll‐like receptors (TLRs) are integral membrane‐bound receptors that are central to innate and adaptive immune responses. They are known to activate a cascade of downstream signals to induce the secretion of inflammatory cytokines, chemokines, and… read more here.
Keywords: dependent signaling; trif dependent; signaling pathways; like receptors ... See more keywords
Activity-dependent Signaling and Epigenetic Abnormalities in Mice Exposed to Postnatal Ethanol
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2018.07.011
Abstract: Postnatal ethanol exposure has been shown to cause persistent defects in hippocampal synaptic plasticity and disrupt learning and memory processes. However, the mechanisms responsible for these abnormalities are less well studied. We evaluated the influence… read more here.
Keywords: signaling epigenetic; postnatal ethanol; ethanol; dependent signaling ... See more keywords
Emerging Trends in Metalloid-Dependent Signaling in Plants.
Sign Up to like & getrecommendations! Published in 2020 at "Trends in plant science"
DOI: 10.1016/j.tplants.2020.11.003
Abstract: Metalloids are semiconducting elements that constitute a small group in the periodic table of elements. Their occurrence in nature either poses an environmental threat or benefit to plants. The precise mechanisms or manner of crosstalk… read more here.
Keywords: metalloid dependent; trends metalloid; emerging trends; signaling plants ... See more keywords
A ubiquitin-dependent signaling axis specific for ALKBH-mediated DNA dealkylation repair
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature24484
Abstract: DNA repair is essential to prevent the cytotoxic or mutagenic effects of various types of DNA lesions, which are sensed by distinct pathways to recruit repair factors specific to the damage type. Although biochemical mechanisms… read more here.
Keywords: alkylating agents; ubiquitin dependent; damage; alkylation ... See more keywords
Nitric oxide dependent signaling via cyclic GMP in dendritic cells regulates migration and T-cell polarization
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-29287-9
Abstract: Allergic airway inflammation is accompanied by excessive generation of nitric oxide (NO). Beside its detrimental activity due to the generation of reactive nitrogen species, NO was found to modulate immune responses by activating the NO-sensitive… read more here.
Keywords: camp; oxide dependent; cyclic gmp; signaling via ... See more keywords
Cardiac inflammatory CD11b/c cells exert a protective role in hypertrophied cardiomyocyte by promoting TNFR2- and Orai3- dependent signaling
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-42452-y
Abstract: Early adaptive cardiac hypertrophy (EACH) is initially a compensatory process to optimize pump function. We reported the emergence of Orai3 activity during EACH. This study aimed to characterize how inflammation regulates store-independent activation of Orai3-calcium… read more here.
Keywords: inflammatory cd11b; orai3 dependent; cd11b; tnfr2 orai3 ... See more keywords
Principles of Ubiquitin-Dependent Signaling.
Sign Up to like & getrecommendations! Published in 2018 at "Annual review of cell and developmental biology"
DOI: 10.1146/annurev-cellbio-100617-062802
Abstract: Ubiquitylation is an essential posttranslational modification that controls cell division, differentiation, and survival in all eukaryotes. By combining multiple E3 ligases (writers), ubiquitin-binding effectors (readers), and de-ubiquitylases (erasers) with functionally distinct ubiquitylation tags, the ubiquitin… read more here.
Keywords: ubiquitin dependent; principles ubiquitin; dependent signaling; biology ... See more keywords
Interferon-dependent signaling is critical for viral clearance in airway neutrophils.
Sign Up to like & getrecommendations! Published in 2023 at "JCI insight"
DOI: 10.1172/jci.insight.167042
Abstract: Neutrophilic inflammation characterizes several respiratory viral infections including COVID-19-related ARDS, although its contribution to disease pathogenesis remains poorly understood. Blood and airway immune cells from 52 severe COVID-19 subjects were phenotyped by flow cytometry. Samples… read more here.
Keywords: clearance; viral clearance; dependent signaling; type interferon ... See more keywords
The θ‐defensin retrocyclin 101 inhibits TLR4‐ and TLR2‐dependent signaling and protects mice against influenza infection
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Leukocyte Biology"
DOI: 10.1189/jlb.2a1215-567rr
Abstract: Despite widespread use of annual influenza vaccines, seasonal influenza‐associated deaths number in the thousands each year, in part because of exacerbating bacterial superinfections. Therefore, discovering additional therapeutic options would be a valuable aid to public… read more here.
Keywords: defensin; retrocyclin 101; infection; influenza ... See more keywords
Selective Inhibition of β-Catenin/Co-Activator Cyclic AMP Response Element-Binding Protein-Dependent Signaling Prevents the Emergence of Hapten-Induced Atopic Dermatitis-Like Dermatitis
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Dermatology"
DOI: 10.5021/ad.2019.31.6.631
Abstract: Background The canonical Wnt/β-catenin signaling pathway is a fundamental regulatory system involved in various biological events. ICG-001 selectively blocks the interaction of β-catenin with its transcriptional co-activator cyclic AMP response element-binding protein (CBP). Recent studies… read more here.
Keywords: catenin; activator cyclic; like dermatitis; icg 001 ... See more keywords
YOD1/TRAF6 association balances p62-dependent IL-1 signaling to NF-κB
Sign Up to like & getrecommendations! Published in 2017 at "eLife"
DOI: 10.7554/elife.22416
Abstract: The ubiquitin ligase TRAF6 is a key regulator of canonical IκB kinase (IKK)/NF-κB signaling in response to interleukin-1 (IL-1) stimulation. Here, we identified the deubiquitinating enzyme YOD1 (OTUD2) as a novel interactor of TRAF6 in… read more here.
Keywords: p62 dependent; traf6; traf6 association; yod1 ... See more keywords