A randomised double-blind placebo-controlled clinical trial of oral hydroxyurea for transfusion-dependent β-thalassaemia
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DOI: 10.1038/s41598-022-06774-8
Abstract: Hydroxyurea is an antimetabolite drug that induces fetal haemoglobin in sickle cell disease. However, its clinical usefulness in β-thalassaemia is unproven. We conducted a randomised, double-blind, placebo-controlled clinical trial to evaluate the efficacy and safety… read more here.
Keywords: transfusion dependent; dependent thalassaemia; transfusion; oral hydroxyurea ... See more keywords
Immune response and adverse events after vaccination against SARS‐CoV‐2 in adult patients with transfusion‐dependent thalassaemia
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DOI: 10.1111/bjh.18146
Abstract: Patients with transfusion‐dependent thalassaemia (TDT) are considered an at increased‐risk population for severe and/or morbid coronavirus disease 2019 (COVID‐19) infection. Timely vaccination is the main preventive method for severe COVID‐19. Different adverse events and reactions… read more here.
Keywords: dependent thalassaemia; adult patients; transfusion dependent; vaccination ... See more keywords
Management of luspatercept therapy in patients with transfusion‐dependent β‐thalassaemia
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DOI: 10.1111/bjh.18801
Abstract: Patients with transfusion‐dependent β‐thalassaemia require lifelong, regular red blood cell transfusions for survival; however, frequent blood transfusions are associated with an increased risk of iron overload, transfusion‐transmitted disease and alloimmunization, as well as reduced quality… read more here.
Keywords: dependent thalassaemia; transfusion dependent; patients transfusion; management ... See more keywords
Psychological morbidity among children with transfusion dependent β-thalassaemia and their parents in Sri Lanka
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DOI: 10.1371/journal.pone.0228733
Abstract: Background Thalassaemia is a chronic disease which requires lifelong treatment in a majority. Despite recent advances in the medical care, minimal attempts are made to improve psychological health in these patients. In this study, we… read more here.
Keywords: thalassaemia; dependent thalassaemia; sri lanka; transfusion dependent ... See more keywords