Amlodipine: Can act as an antioxidant in patients with transfusion‐dependent β‐thalassemia? A double‐blind, controlled, crossover trial
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24752
Abstract: This study aimed to assess the antioxidant effects of amlodipine in transfusion‐dependent β‐thalassemia (TDT) patients. read more here.
Keywords: dependent thalassemia; act antioxidant; transfusion dependent; amlodipine act ... See more keywords
A high frequency of Gilbert syndrome (UGT1A1*28/*28) and associated hyperbilirubinemia but not cholelithiasis in adolescent and adult north Indian patients with transfusion-dependent β-thalassemia
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Hematology"
DOI: 10.1007/s00277-020-04176-2
Abstract: Hyperbilirubinemia and pigment gallstones are frequent complications in transfusion-dependent β-thalassemia (TDβT) patients. Bilirubin production and clearance are determined by genetic as well as environmental variables like ineffective erythropoiesis, hemolysis, infection-induced hepatic injury, and drug- or… read more here.
Keywords: gilbert syndrome; transfusion dependent; transfusion; total unconjugated ... See more keywords
Vitamin C Deficiency and Oxidant Levels in Children With Transfusion-Dependent β-Thalassemia
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DOI: 10.1007/s13312-021-2257-8
Abstract: To study vitamin C levels in children with transfusion-dependent β-thalassemia and correlate with age, transfusions received and iron overload; and to study the effect of administering vitamin C on its levels and Malondialdehyde (MDA) in… read more here.
Keywords: transfusion dependent; vitamin levels; vitamin; deficiency ... See more keywords
Non-Myeloablative Bone Marrow Transplant with Post-Transplant Cyclophosphamide Plus Thiotepa Improves Donor Engraftment in Patients with Transfusion Dependent Thalassemia: Results of an International Consortium (VGC2)
Sign Up to like & getrecommendations! Published in 2020 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2019.12.540
Abstract: Background Post-transplant cyclophosphamide (PTCy) enables allogeneic hematopoietic cell transplant (Allo-HCT) across the human leukocyte antigen barrier. Allo-HCT for severe transfusion dependent thalassemia is restricted in its application due to limited donor availability, graft rejection, and… read more here.
Keywords: bone marrow; transfusion dependent; transplant; dependent thalassemia ... See more keywords
Hemoglobin disorders: lentiviral gene therapy in the starting blocks to enter clinical practice.
Sign Up to like & getrecommendations! Published in 2018 at "Experimental hematology"
DOI: 10.1016/j.exphem.2018.05.004
Abstract: The β-hemoglobinopathies, transfusion-dependent β-thalassemia and sickle cell disease, are the most prevalent inherited disorders worldwide and affect millions of people. Many of these patients have a shortened life expectancy and suffer from severe morbidity despite… read more here.
Keywords: gene therapy; transfusion dependent; gene; cell ... See more keywords
Hydroxyurea for nontransfusion-dependent β-thalassemia: A systematic review and meta-analysis.
Sign Up to like & getrecommendations! Published in 2017 at "Hematology/oncology and stem cell therapy"
DOI: 10.1016/j.hemonc.2017.02.002
Abstract: OBJECTIVE/BACKGROUND Nontransfusion-dependent β-thalassemia (NTDβT) syndromes consist of β-thalassemia intermedia and moderate hemoglobin E/β thalassemias. They are characterized by varying degrees of chronic anemia and a wide spectrum of complications due to ineffective erythropoiesis and iron… read more here.
Keywords: analysis; dependent thalassemia; nontransfusion dependent; meta analysis ... See more keywords
Construction of an exposure-pathway-phenotype in children with depression due to transfusion-dependent thalassemia: Results of (un)supervised machine learning.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of affective disorders"
DOI: 10.1016/j.jad.2020.12.089
Abstract: BACKGROUND Transfusion dependent thalassemia (TDT) patients are treated with continued blood transfusions and show a higher prevalence of depression. TDT with consequent iron overload and inflammation is associated with increased severity of depressive symptoms in… read more here.
Keywords: depression; exposure; transfusion dependent; iron overload ... See more keywords
Safety and efficacy of deferasirox in patients with transfusion-dependent thalassemia: A 4-year single-center experience
Sign Up to like & getrecommendations! Published in 2021 at "Pediatric Hematology and Oncology"
DOI: 10.1080/08880018.2021.1901809
Abstract: Abstract This study was organized to determine the efficacy and safety of deferasirox (DFX) in reducing the SF of patients with transfusion-dependent thalassemia (TDT). This is a retrospective, descriptive study of 101 transfusion- dependent patients… read more here.
Keywords: safety; transfusion dependent; efficacy; transfusion ... See more keywords
Association study of rs10768683 and rs968857 polymorphisms with transfusion-dependent thalassemia (TDT) in a southern Iranian population
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DOI: 10.1080/15257770.2018.1498514
Abstract: Abstract Previous studies reported that detection of polymorphisms inherited through paternal model could be potential markers for the Non-Invasive Prenatal Diagnosis (NIPD) of β-thalassemia. The aim of the current study was to find out the… read more here.
Keywords: tdt; thalassemia; study; transfusion dependent ... See more keywords
Wrist Joint Skeletal Changes in Children With Transfusion-Dependent Thalassemia.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Pediatric Orthopaedics"
DOI: 10.1097/bpo.0000000000001523
Abstract: BACKGROUND Arthropathies and bone deformities are well known to occur in patients with thalassemia major and have been attributed to the disease or to its therapy. Before the advent of chelation therapy, these children developed… read more here.
Keywords: therapy; transfusion dependent; thalassemia; dependent thalassemia ... See more keywords
Stratification for Age in Transfusion-Dependent Thalassemia
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DOI: 10.1182/blood-2018-99-112042
Abstract: Introduction. Transfusion-dependent β-thalassemia (TDT) is the most severe clinical form of β-thalassemia and requires regular long-term red cell transfusions for survival. This study aimed to examine the association of age with the presence of iron… read more here.
Keywords: age; group; transfusion dependent; iron ... See more keywords