MDB-66. HIGH-THROUGHPUT SMALL MOLECULE DRUG SCREENING, TRANSCRIPTOMICS AND INTEGRATIVE AI IDENTIFY TARGETABLE MYC-DEPENDENT THERAPEUTIC VULNERABILITIES IN HIGH-RISK MEDULLOBLASTOMA
Sign Up to like & getrecommendations! Published in 2024 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noae064.516
Abstract: Abstract INTRODUCTION MYC-amplified Group 3 medulloblastomas (MBGroup3-MYC) do not respond to conventional up-front therapies and are almost universally fatal (500 clinically-actionable compounds). Bespoke integrative AI tools and bioinformatic analysis, and subsequent siRNA/pharmacodynamic validation, identified and… read more here.
Keywords: high throughput; dependent therapeutic; drug; myc ... See more keywords
Shape Dependent Therapeutic Potential of Nanoparticulate System: Advance Approach for Drug Delivery.
Sign Up to like & getrecommendations! Published in 2024 at "Current pharmaceutical design"
DOI: 10.2174/0113816128314618240628110218
Abstract: Drug delivery systems rely heavily on nanoparticles because they provide a targeted and monitored release of pharmaceuticals that maximize therapeutic efficacy and minimize side effects. To maximize drug internalization, this review focuses on comprehending the… read more here.
Keywords: dependent therapeutic; shape dependent; drug delivery; shape ... See more keywords