Crystal structures of manganese-dependent transcriptional repressor MntR (Rv2788) from Mycobacterium tuberculosis in apo and manganese bound forms.
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DOI: 10.1016/j.bbrc.2018.05.005
Abstract: The pathogenic Mycobacterium tuberculosis encodes two members of the DtxR family metalloregulators, IdeR and MntR. IdeR represses gene expression in response to ferrous iron, while MntR (Rv2788) functions as a manganese-dependent transcriptional repressor, which represses… read more here.
Keywords: mntr rv2788; manganese dependent; transcriptional repressor; dependent transcriptional ... See more keywords
Activity-dependent transcriptional programs in memory regulate motor recovery after stroke
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DOI: 10.1038/s42003-024-06723-3
Abstract: Stroke causes death of brain tissue leading to long-term deficits. Behavioral evidence from neurorehabilitative therapies suggest learning-induced neuroplasticity can lead to beneficial outcomes. However, molecular and cellular mechanisms that link learning and stroke recovery are… read more here.
Keywords: activity dependent; dependent transcriptional; activity; transcriptional programs ... See more keywords
An early Myc‐dependent transcriptional program orchestrates cell growth during B‐cell activation
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DOI: 10.15252/embr.201947987
Abstract: Upon activation, lymphocytes exit quiescence and undergo substantial increases in cell size, accompanied by activation of energy‐producing and anabolic pathways, widespread chromatin decompaction, and elevated transcriptional activity. These changes depend upon prior induction of the… read more here.
Keywords: early myc; dependent transcriptional; activation; cell ... See more keywords