4EGI-1 represses cap-dependent translation and regulates genome-wide translation in malignant pleural mesothelioma
Sign Up to like & getrecommendations! Published in 2017 at "Investigational New Drugs"
DOI: 10.1007/s10637-017-0535-z
Abstract: SummaryDeregulation of cap-dependent translation has been implicated in the malignant transformation of numerous human tissues. 4EGI-1, a novel small-molecule inhibitor of cap-dependent translation, disrupts formation of the eukaryotic initiation factor 4F (eIF4F) complex. The effects… read more here.
Keywords: genome wide; dependent translation; pleural mesothelioma; malignant pleural ... See more keywords
The diversity, plasticity, and adaptability of cap-dependent translation initiation and the associated machinery
Sign Up to like & getrecommendations! Published in 2020 at "RNA Biology"
DOI: 10.1080/15476286.2020.1766179
Abstract: ABSTRACT Translation initiation is a critical facet of gene expression with important impacts that underlie cellular responses to stresses and environmental cues. Its dysregulation in many diseases position this process as an important area for… read more here.
Keywords: translation initiation; translation; dependent translation; cap dependent ... See more keywords
IDH1 fine-tunes cap-dependent translation initiation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Cell Biology"
DOI: 10.1093/jmcb/mjz082
Abstract: Abstract The metabolic enzyme isocitrate dehydrogenase 1 (IDH1) catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate (α-KG). Its mutation often leads to aberrant gene expression in cancer. IDH1 was reported to bind thousands of RNA… read more here.
Keywords: dependent translation; translation initiation; idh1 fine; idh1 ... See more keywords
KRASG12C Can Either Promote or Impair Cap-Dependent Translation in Two Different Lung Adenocarcinoma Cell Lines
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DOI: 10.3390/ijms22042222
Abstract: KRASG12C is among the most common oncogenic mutations in lung adenocarcinoma and a promising target for treatment by small-molecule inhibitors. KRAS oncogenic signaling is responsible for modulation of tumor microenvironment, with translation factors being among… read more here.
Keywords: lung adenocarcinoma; dependent translation; translation; cell ... See more keywords
DDX21, a Host Restriction Factor of FMDV IRES-Dependent Translation and Replication
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DOI: 10.3390/v13091765
Abstract: In cells, the contributions of DEAD-box helicases (DDXs), without which cellular life is impossible, are of utmost importance. The extremely diverse roles of the nucleolar helicase DDX21, ranging from fundamental cellular processes such as cell… read more here.
Keywords: ires dependent; fmdv ires; dependent translation; ddx21 ... See more keywords
Translation initiation mediated by nuclear cap-binding protein complex
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DOI: 10.5483/bmbrep.2017.50.4.007
Abstract: In mammals, cap-dependent translation of mRNAs is initiated by two distinct mechanisms: cap-binding complex (CBC; a heterodimer of CBP80 and 20)-dependent translation (CT) and eIF4E-dependent translation (ET). Both translation initiation mechanisms share common features in… read more here.
Keywords: cap binding; translation; dependent translation; translation initiation ... See more keywords
Translation inhibitory elements from Hoxa3 and Hoxa11 mRNAs use uORFs for translation inhibition
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DOI: 10.7554/elife.66369
Abstract: During embryogenesis, Hox mRNA translation is tightly regulated by a sophisticated molecular mechanism that combines two RNA regulons located in their 5’UTR. First, an internal ribosome entry site (IRES) enables cap-independent translation. The second regulon… read more here.
Keywords: dependent translation; translation; cap dependent; translation inhibition ... See more keywords