Activation and Hydroxylation Mechanism of Aromatic C-H and C-F of 3-Fluoro-l-tyrosine Catalyzed by the Heme-Dependent Tyrosine Hydroxylase
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DOI: 10.1021/acs.jcim.5c02190
Abstract: LmbB2 is a peroxygenase-like heme-dependent l-tyrosine hydroxylase (TyrH) that hydroxylates natural l-tyrosine to L-3,4-dihydroxyphenylalanine (DOPA). When challenged with 3-fluoro-l-tyrosine as a substrate, both the C-H and C-F bonds can be hydroxylated, leading to two products,… read more here.
Keywords: heme dependent; dependent tyrosine; tyrosine hydroxylase; fluoro tyrosine ... See more keywords
Molecular Rationale for Partitioning between C-H and C-F Bond Activation in Heme-Dependent Tyrosine Hydroxylase.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c00175
Abstract: The heme-dependent l-tyrosine hydroxylases (TyrHs) in natural product biosynthesis constitute a new enzyme family in contrast to the nonheme iron enzymes for DOPA production. A representative TyrH exhibits dual reactivity of C-H and C-F bond… read more here.
Keywords: bond; dependent tyrosine; tyrosine; bond activation ... See more keywords