m6A-dependent upregulation of TRAF6 by METTL3 is associated with metastatic osteosarcoma
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone Oncology"
DOI: 10.1016/j.jbo.2022.100411
Abstract: Highlights • METTL3 is highly expressed in osteosarcoma.• METTL3 downregulation inhibits metastases of osteosarcoma cells.• m6A regulates osteosarcoma cell activity.• METTL3 modifies TRAF6 activity via m6A.• TRAF6 inhibits the repressive effects of sh-METTL3 on osteosarcoma… read more here.
Keywords: upregulation traf6; mettl3; m6a dependent; osteosarcoma ... See more keywords
SNAI1-dependent upregulation of CD73 increases extracellular adenosine release to mediate immune suppression in TNBC
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.982821
Abstract: Triple-negative subtype of breast cancer (TNBC) is hallmarked by frequent disease relapse and shows highest mortality rate. Although PD-1/PD-L1 immune checkpoint blockades have recently shown promising clinical benefits, the overall response rate remains largely insufficient.… read more here.
Keywords: cd73; snai1 dependent; dependent upregulation; tnbc ... See more keywords