Connexin 43 dephosphorylation contributes to arrhythmias and cardiomyocyte apoptosis in ischemia/reperfusion hearts
Sign Up to like & getrecommendations! Published in 2019 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-019-0748-8
Abstract: Connexin 43 (Cx43)-associated gap junctions form electrical and mechanical conduits between adjacent ventricular cardiomyocytes, ensuring coordinate electrical excitation and synchronic contraction for each heartbeat. Cx43 dephosphorylation is a characteristic of ischemia, arrhythmia, and a failing… read more here.
Keywords: fas; apoptosis; dephosphorylation; ischemia reperfusion ... See more keywords
Dephosphorylation of Girdin by PP2A inhibits breast cancer metastasis.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.03.167
Abstract: Dysfunction of Girdin plays a crucial role in the development of a variety of tumors. Phosphorylated regulation of Girdin has been studied extensively. However, how Girdin is dephosphorylated remains unclear. In this study, we report… read more here.
Keywords: dephosphorylation; girdin; pp2a; breast cancer ... See more keywords
A Tyrosine Phosphoproteome Analysis Approach Enabled by Selective Dephosphorylation with Protein Tyrosine Phosphatase.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.1c03704
Abstract: Protein tyrosine phosphorylation (pTyr) plays a prominent role in signal transduction and regulation in all eukaryotic cells. In conventional immunoaffinity purification (IP) methods, phosphotyrosine peptides are isolated from the digest of cellular protein extracts with… read more here.
Keywords: protein tyrosine; tyrosine; dephosphorylation; phosphotyrosine peptides ... See more keywords
Targeting the Allosteric Pathway That Interconnects the Core-Functional Scaffold and the Distal Phosphorylation Sites for Specific Dephosphorylation of Bcl-2.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c01290
Abstract: Protein phosphorylation is the most significant post-translational modification for regulating cellular activities, but site-specific modulation of phosphorylation is still challenging. Using three-dimensional NMR spectra, molecular dynamics simulations, and alanine mutations, we identified that the interaction… read more here.
Keywords: dephosphorylation bcl; phosphorylation sites; dephosphorylation; targeting allosteric ... See more keywords
Highly Efficient Mesoporous Carbonaceous CeO2 Catalyst for Dephosphorylation
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c01832
Abstract: Phosphorus is fast becoming a critical element, as the global supply and demand are reaching unsustainable levels. Herein, the synthesis, characterization, and applicability of a novel biomass-derived mesoporous carbonaceous material decorated with CeO2 (CeO2-S400) as… read more here.
Keywords: dephosphorylation; catalyst dephosphorylation; ceo2 s400; mesoporous carbonaceous ... See more keywords
Protein Phosphatase 5-Recruiting Chimeras for Accelerating Apoptosis-Signal-Regulated Kinase 1 Dephosphorylation with Antiproliferative Activity.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c10759
Abstract: A normal phosphorylation state is essential for the function of proteins. Biased regulation frequently results in morbidity, especially for the hyperphosphorylation of oncoproteins. The hyperphosphorylation of ASK1 at Thr838 leads to a persistently high activity… read more here.
Keywords: dephosphorylation; phosphatase recruiting; activity; protein phosphatase ... See more keywords
Phosphoprotein Analysis by MALDI-TOF Mass Spectrometry using On-Probe Tandem Proteolysis and Dephosphorylation
Sign Up to like & getrecommendations! Published in 2017 at "Analytical Letters"
DOI: 10.1080/00032719.2016.1229785
Abstract: ABSTRACT In this investigation, methods based on on-probe enzymatic cleavage matrix-assisted laser desorption/ionization time-of-flight mass spectrometric (MALDI-TOF-MS) analyses have been developed, allowing the rapid assignment of phosphorylation sites within phosphoproteins. The procedures involved robotic sample… read more here.
Keywords: proteolysis; probe; phosphoprotein; mass ... See more keywords
Nucleoside Triphosphate Diphosphohydrolase 1 Exhibits Enzymatic Activity toward Tenofovir Diphosphate
Sign Up to like & getrecommendations! Published in 2022 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.122.000855
Abstract: Tenofovir (TFV; prescribed as TFV disoproxil fumarate and TFV alafenamide prodrugs) is currently used for HIV prevention and treatment. TFV must be phosphorylated twice into TFV-diphosphate (TFV-DP) to become pharmacologically active. Previously, we reported heterogeneity… read more here.
Keywords: dephosphorylation; ntpdase; tfv; colorectal tissue ... See more keywords
The kinetoplastid-specific phosphatase KPP1 attenuates PLK activity to facilitate flagellum inheritance in Trypanosoma brucei
Sign Up to like & getrecommendations! Published in 2021 at "Science Signaling"
DOI: 10.1126/scisignal.abc6435
Abstract: Flagellum inheritance in trypanosomes requires strategically timed suppression of Polo-like kinase activity. Passing the flagellum in trypanosomes The single flagellum of the unicellular parasite Trypanosoma brucei is critical for virulence, and Polo-like kinase (TbPLK) is… read more here.
Keywords: flagellum inheritance; inheritance; activity; flagellum ... See more keywords
Improved α-Amylase Production by Dephosphorylation Mutation of CreD, an Arrestin-Like Protein Required for Glucose-Induced Endocytosis of Maltose Permease and Carbon Catabolite Derepression in Aspergillusoryzae
Sign Up to like & getrecommendations! Published in 2017 at "Applied and Environmental Microbiology"
DOI: 10.1128/aem.00592-17
Abstract: ABSTRACT Aspergillus oryzae produces copious amount of amylolytic enzymes, and MalP, a major maltose permease, is required for the expression of amylase-encoding genes. The expression of these genes is strongly repressed by carbon catabolite repression… read more here.
Keywords: production; amylase; endocytosis; dephosphorylation ... See more keywords
Abstract 5442: Dose-dependent toxicity of FTY720, a sphingosine-1-phosphate receptor agonist, on double hit lymphoma cells via PP2A-mediated dephosphorylation of c-myc and bcl-2
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-5442
Abstract: High grade B cell lymphoma with translocations involving MYC and rearrangements involving BCL2 and/or BCL6 define an aggressive subtype of diffuse large B cell lymphoma (DLBCL) with poor prognosis and high rates of relapse. The… read more here.
Keywords: lymphoma; pp2a; dephosphorylation; bcl ... See more keywords