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   Articles with "dephosphorylation" as a keyword



Connexin 43 dephosphorylation contributes to arrhythmias and cardiomyocyte apoptosis in ischemia/reperfusion hearts

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recommendations! Published in 2019 at "Basic Research in Cardiology"

DOI: 10.1007/s00395-019-0748-8

Abstract: Connexin 43 (Cx43)-associated gap junctions form electrical and mechanical conduits between adjacent ventricular cardiomyocytes, ensuring coordinate electrical excitation and synchronic contraction for each heartbeat. Cx43 dephosphorylation is a characteristic of ischemia, arrhythmia, and a failing… read more here.

Keywords: fas; apoptosis; dephosphorylation; ischemia reperfusion ... See more keywords

Dephosphorylation of Girdin by PP2A inhibits breast cancer metastasis.

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recommendations! Published in 2019 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2019.03.167

Abstract: Dysfunction of Girdin plays a crucial role in the development of a variety of tumors. Phosphorylated regulation of Girdin has been studied extensively. However, how Girdin is dephosphorylated remains unclear. In this study, we report… read more here.

Keywords: dephosphorylation; girdin; pp2a; breast cancer ... See more keywords

A Tyrosine Phosphoproteome Analysis Approach Enabled by Selective Dephosphorylation with Protein Tyrosine Phosphatase.

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recommendations! Published in 2022 at "Analytical chemistry"

DOI: 10.1021/acs.analchem.1c03704

Abstract: Protein tyrosine phosphorylation (pTyr) plays a prominent role in signal transduction and regulation in all eukaryotic cells. In conventional immunoaffinity purification (IP) methods, phosphotyrosine peptides are isolated from the digest of cellular protein extracts with… read more here.

Keywords: protein tyrosine; tyrosine; dephosphorylation; phosphotyrosine peptides ... See more keywords
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Targeting the Allosteric Pathway That Interconnects the Core-Functional Scaffold and the Distal Phosphorylation Sites for Specific Dephosphorylation of Bcl-2.

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recommendations! Published in 2020 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.0c01290

Abstract: Protein phosphorylation is the most significant post-translational modification for regulating cellular activities, but site-specific modulation of phosphorylation is still challenging. Using three-dimensional NMR spectra, molecular dynamics simulations, and alanine mutations, we identified that the interaction… read more here.

Keywords: dephosphorylation bcl; phosphorylation sites; dephosphorylation; targeting allosteric ... See more keywords

Highly Efficient Mesoporous Carbonaceous CeO2 Catalyst for Dephosphorylation

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recommendations! Published in 2022 at "ACS Omega"

DOI: 10.1021/acsomega.2c01832

Abstract: Phosphorus is fast becoming a critical element, as the global supply and demand are reaching unsustainable levels. Herein, the synthesis, characterization, and applicability of a novel biomass-derived mesoporous carbonaceous material decorated with CeO2 (CeO2-S400) as… read more here.

Keywords: dephosphorylation; catalyst dephosphorylation; ceo2 s400; mesoporous carbonaceous ... See more keywords

Protein Phosphatase 5-Recruiting Chimeras for Accelerating Apoptosis-Signal-Regulated Kinase 1 Dephosphorylation with Antiproliferative Activity.

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recommendations! Published in 2022 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.2c10759

Abstract: A normal phosphorylation state is essential for the function of proteins. Biased regulation frequently results in morbidity, especially for the hyperphosphorylation of oncoproteins. The hyperphosphorylation of ASK1 at Thr838 leads to a persistently high activity… read more here.

Keywords: dephosphorylation; phosphatase recruiting; activity; protein phosphatase ... See more keywords

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation

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recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-024-45683-4

Abstract: The Eyes Absent proteins (EYA1-4) are a biochemically unique group of tyrosine phosphatases known to be tumour-promoting across a range of cancer types. To date, the targets of EYA phosphatase activity remain largely uncharacterised. Here,… read more here.

Keywords: eya4 eya1; eyes absent; dephosphorylation; plk1 activation ... See more keywords

Phosphoprotein Analysis by MALDI-TOF Mass Spectrometry using On-Probe Tandem Proteolysis and Dephosphorylation

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recommendations! Published in 2017 at "Analytical Letters"

DOI: 10.1080/00032719.2016.1229785

Abstract: ABSTRACT In this investigation, methods based on on-probe enzymatic cleavage matrix-assisted laser desorption/ionization time-of-flight mass spectrometric (MALDI-TOF-MS) analyses have been developed, allowing the rapid assignment of phosphorylation sites within phosphoproteins. The procedures involved robotic sample… read more here.

Keywords: proteolysis; probe; phosphoprotein; mass ... See more keywords

GPSD: a hybrid learning framework for the prediction of phosphatase-specific dephosphorylation sites

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recommendations! Published in 2024 at "Briefings in Bioinformatics"

DOI: 10.1093/bib/bbae694

Abstract: Abstract Protein phosphorylation is dynamically and reversibly regulated by protein kinases and protein phosphatases, and plays an essential role in orchestrating a wide range of biological processes. Although a number of tools have been developed… read more here.

Keywords: dephosphorylation; prediction; dephosphorylation sites; phosphatase specific ... See more keywords

Nucleoside Triphosphate Diphosphohydrolase 1 Exhibits Enzymatic Activity toward Tenofovir Diphosphate

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recommendations! Published in 2022 at "Drug Metabolism and Disposition"

DOI: 10.1124/dmd.122.000855

Abstract: Tenofovir (TFV; prescribed as TFV disoproxil fumarate and TFV alafenamide prodrugs) is currently used for HIV prevention and treatment. TFV must be phosphorylated twice into TFV-diphosphate (TFV-DP) to become pharmacologically active. Previously, we reported heterogeneity… read more here.

Keywords: dephosphorylation; ntpdase; tfv; colorectal tissue ... See more keywords

EGFR targeting PhosTACs as a dual inhibitory approach reveals differential downstream signaling

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recommendations! Published in 2024 at "Science Advances"

DOI: 10.1126/sciadv.adj7251

Abstract: We recently developed a heterobifunctional approach [phosphorylation targeting chimeras (PhosTACs)] to achieve the targeted protein dephosphorylation (TPDephos). Here, we envisioned combining the inhibitory effects of receptor tyrosine kinase inhibitors (RTKIs) and the active dephosphorylation by… read more here.

Keywords: phostacs dual; egfr targeting; dephosphorylation; targeting phostacs ... See more keywords