Targeting the Allosteric Pathway That Interconnects the Core-Functional Scaffold and the Distal Phosphorylation Sites for Specific Dephosphorylation of Bcl-2.
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DOI: 10.1021/acs.jmedchem.0c01290
Abstract: Protein phosphorylation is the most significant post-translational modification for regulating cellular activities, but site-specific modulation of phosphorylation is still challenging. Using three-dimensional NMR spectra, molecular dynamics simulations, and alanine mutations, we identified that the interaction… read more here.
Keywords: dephosphorylation bcl; phosphorylation sites; dephosphorylation; targeting allosteric ... See more keywords