ZAR1 knockdown promotes the differentiation of human neuroblastoma cells by suppression of MYCN expression
Sign Up to like & getrecommendations! Published in 2017 at "Medical Oncology"
DOI: 10.1007/s12032-017-0999-x
Abstract: Although DNA hypermethylation at non-promoter region of the Zygote arrest 1 (ZAR1) gene has been observed in many types of tumor, including neuroblastoma (NB), the role of this gene in tumor development and/or progression is… read more here.
Keywords: mycn expression; zar1; expression; depleted cells ... See more keywords
PARP activity fine-tunes the DNA replication choreography of Chk1-depleted cells.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2021.166949
Abstract: Checkpoint Kinase 1 (Chk1) prevents DNA damage by adjusting the replication choreography in the face of replication stress. Chk1 depletion provokes slow and asymmetrical fork movement, yet the signals governing such changes remain unclear. We… read more here.
Keywords: chk1; replication choreography; fork; chk1 depleted ... See more keywords
Cellular Depletion of BRD8 Causes p53-Dependent Apoptosis and Induces a DNA Damage Response in Non-Stressed Cells
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DOI: 10.1038/s41598-018-32323-3
Abstract: Regulation of the chromatin state is crucial for biological processes such as the regulation of transcription, DNA replication, and DNA damage repair. Here we show that knockdown of the BRD8 bromodomain protein – a subunit… read more here.
Keywords: dna damage; damage response; brd8; depleted cells ... See more keywords
Oxidation resistance 1 prevents genome instability through maintenance of G2/M arrest in gamma-ray-irradiated cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Radiation Research"
DOI: 10.1093/jrr/rrz080
Abstract: ABSTRACT Human oxidation resistance 1 (OXR1) was identified as a protein that decreases genomic mutations in Escherichia coli caused by oxidative DNA damage. However, the mechanism by which OXR1 defends against genome instability has not… read more here.
Keywords: oxr1 depleted; genome instability; depleted cells; oxidation resistance ... See more keywords