Selective cytotoxicity of the anti-diabetic drug, metformin, in glucose-deprived chicken DT40 cells
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DOI: 10.1371/journal.pone.0185141
Abstract: Metformin is a biguanide drug that is widely used in the treatment of diabetes. Epidemiological studies have indicated that metformin exhibits anti-cancer activity. However, the molecular mechanisms underlying this activity currently remain unclear. We hypothesized… read more here.
Keywords: chicken dt40; depleted conditions; selective cytotoxicity; metformin glucose ... See more keywords
Arabidopsis Phosphatidic Acid Phosphohydrolases Are Essential for Growth under Nitrogen-Depleted Conditions
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DOI: 10.3389/fpls.2017.01847
Abstract: The Arabidopsis homologs of mammalian lipin, PAH1 and PAH2, are cytosolic phosphatidic acid phosphohydrolases that are involved in phospholipid biosynthesis and are essential for growth under phosphate starvation. Here, pah1 pah2 double-knockout mutants were found… read more here.
Keywords: depleted conditions; pah1 pah2; pah1; phosphatidic acid ... See more keywords