Polyamines interfere with protein ubiquitylation and cause depletion of intracellular amino acids: a possible mechanism for cell growth inhibition
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13299
Abstract: Spermidine is a polyamine present in eukaryotes with essential functions in protein synthesis. At high concentrations spermidine and norspermidine inhibit growth by unknown mechanisms. Transcriptomic analysis of the effect of norspermidine on the plant Arabidopsis… read more here.
Keywords: amino acids; protein ubiquitylation; growth inhibition; depletion ... See more keywords
Dosing optimization of CCR4 immunotoxin for improved depletion of CCR4+ Treg in nonhuman primates
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12331
Abstract: Recently, we have developed a diphtheria toxin‐based recombinant anti‐human CCR4 immunotoxin for targeting CCR4+ tumors and Tregs. In this study, we further optimized the dosing schedule for improved CCR4+ Treg depletion. We have demonstrated that… read more here.
Keywords: depletion; ccr4; ccr4 immunotoxin; ccr4 treg ... See more keywords
LABORATORY EXPERIMENTS SIMULATING POROELASTIC STRESS CHANGES ASSOCIATED WITH DEPLETION AND INJECTION IN LOW‐POROSITY SEDIMENTARY ROCKS
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Geophysical Research"
DOI: 10.1002/2016jb013668
Abstract: We characterized the poroelastic deformation of six cores from three formations associated with the Bakken play in the Williston Basin (the Lodgepole, Middle Bakken, and Three Forks formations). All are low-porosity, low-permeability formations, but vary… read more here.
Keywords: stress changes; depletion injection; stress; depletion ... See more keywords
Northern hemisphere stratospheric ozone depletion caused by solar proton events: the role of the polar vortex
Sign Up to like & getrecommendations! Published in 2018 at "Geophysical Research Letters"
DOI: 10.1002/2017gl075966
Abstract: Ozonesonde data from four sites are analyzed in relation to 191 solar protons events (SPEs) from 1989-2016. Analysis shows ozone depletion (~10-35 km altitude) commencing following the SPEs. Seasonally-corrected ozone data demonstrate that depletions occur… read more here.
Keywords: stratospheric ozone; polar vortex; ozone; depletion ... See more keywords
Knockdown of TMEM160 leads to an increase in reactive oxygen species generation and the induction of the mitochondrial unfolded protein response
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13496
Abstract: Transmembrane protein 160 (TMEM160) was recently reported to be localized to the mitochondrial inner membrane, but mitochondrial function was noted to be unaffected by loss of TMEM160. In contrast to these previously published findings, we… read more here.
Keywords: tmem160 depletion; depletion; generation; mitochondrial unfolded ... See more keywords
A Mitochondria-Targeted Ferroptosis Inducer Activated by Glutathione-Responsive Imaging and Depletion for Triple Negative Breast Cancer Theranostics.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300220
Abstract: Ferroptosis is a new type of iron-dependent programmed cell death characterized by glutathione (GSH) depletion, selenoprotein glutathione peroxidase 4 (GPX4) inactivation and lipid peroxides accumulation. Mitochondria, as the main source of intracellular energy supply and… read more here.
Keywords: ferroptosis inducer; depletion; triple negative; ferroptosis ... See more keywords
Irreversible Multi‐Band Effects and Lifshitz Transitions at the LaAlO3/SrTiO3 Interface Under Field Effect
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Electronic Materials"
DOI: 10.1002/aelm.202001120
Abstract: In this work, the irreversible effects of an applied electric field on the magnetotransport properties of LaAlO3/SrTiO3 conducting interfaces are investigated, with focus on their multiband character. Samples of different types, namely with either crystalline… read more here.
Keywords: field; crystalline amorphous; depletion; band ... See more keywords
The Sticky Anchor Hypothesis: Ego Depletion Increases Susceptibility to Situational Cues
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Behavioral Decision Making"
DOI: 10.1002/bdm.2022
Abstract: Self-control depletion has been linked both to increased selfish behavior and increased susceptibility to situational cues. The present research tested two competing hypotheses about the consequence of depletion by measuring how people allocate rewards between… read more here.
Keywords: anchor hypothesis; sticky anchor; situational cues; depletion ... See more keywords
Liquid‐phase based separation systems for depletion, prefractionation, and enrichment of proteins in biological fluids and matrices for in‐depth proteomics analysis—An update covering the period 2014–2016
Sign Up to like & getrecommendations! Published in 2017 at "ELECTROPHORESIS"
DOI: 10.1002/elps.201600413
Abstract: This review article is an update of our previous one by C. Puangpila, E. Mayadunne, and Z. El Rassi, Electrophoresis 2015, 36, 238–252. Similarly to the previous article, this review has two main topics, including… read more here.
Keywords: prefractionation; enrichment; article; separation ... See more keywords
Microglial depletion abolishes ischemic preconditioning in white matter
Sign Up to like & getrecommendations! Published in 2021 at "Glia"
DOI: 10.1002/glia.24132
Abstract: Ischemic preconditioning (IPC) is a phenomenon whereby a brief, non‐injurious ischemic exposure enhances tolerance to a subsequent ischemic challenge. The mechanism of IPC has mainly been studied in rodent stroke models where gray matter (GM)… read more here.
Keywords: white matter; depletion; preconditioned mons; ipc ... See more keywords
Transient Kupffer cell depletion and subsequent replacement by infiltrating monocyte‐derived cells does not alter the induction or progression of hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Cancer"
DOI: 10.1002/ijc.34505
Abstract: Due to a combination of rapid disease progression and the lack of curative treatment options, hepatocellular carcinoma (HCC) is one of the deadliest cancers worldwide. Infiltrated, monocyte‐derived, tumor‐associated macrophages are known to play a role… read more here.
Keywords: hepatocellular carcinoma; progression; depletion; monocyte derived ... See more keywords