RB depletion is required for the continuous growth of tumors initiated by loss of RB
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DOI: 10.1371/journal.pgen.1009941
Abstract: The retinoblastoma (RB) tumor suppressor is functionally inactivated in a wide range of human tumors where this inactivation promotes tumorigenesis in part by allowing uncontrolled proliferation. RB has been extensively studied, but its mechanisms of… read more here.
Keywords: initiated loss; continuous growth; depletion required; loss ... See more keywords